Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1183345..1183759 | Replicon | chromosome |
| Accession | NZ_CP051479 | ||
| Organism | Staphylococcus aureus strain NGA76 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | HF085_RS05885 | Protein ID | WP_249739960.1 |
| Coordinates | 1183508..1183759 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HF085_RS05880 | Protein ID | WP_168777632.1 |
| Coordinates | 1183345..1183518 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HF085_RS05835 (1179474) | 1179474..1180751 | - | 1278 | WP_216734469.1 | PBSX family phage terminase large subunit | - |
| HF085_RS05840 (1180738) | 1180738..1181178 | - | 441 | WP_001003271.1 | terminase small subunit | - |
| HF085_RS05845 (1181365) | 1181365..1181784 | - | 420 | WP_000058633.1 | transcriptional regulator | - |
| HF085_RS05850 (1181799) | 1181799..1181945 | - | 147 | WP_000989997.1 | hypothetical protein | - |
| HF085_RS05855 (1181946) | 1181946..1182119 | - | 174 | WP_070014293.1 | transcriptional activator RinB | - |
| HF085_RS05860 (1182116) | 1182116..1182322 | - | 207 | WP_054189015.1 | DUF1381 domain-containing protein | - |
| HF085_RS05865 (1182359) | 1182359..1182886 | - | 528 | WP_117216027.1 | dUTPase | - |
| HF085_RS05870 (1182901) | 1182901..1183062 | - | 162 | WP_168777631.1 | hypothetical protein | - |
| HF085_RS05875 (1183063) | 1183063..1183344 | - | 282 | WP_147701981.1 | hypothetical protein | - |
| HF085_RS05880 (1183345) | 1183345..1183518 | - | 174 | WP_168777632.1 | hypothetical protein | Antitoxin |
| HF085_RS05885 (1183508) | 1183508..1183759 | - | 252 | WP_249739960.1 | DUF1024 family protein | Toxin |
| HF085_RS05890 (1183752) | 1183752..1184060 | - | 309 | WP_249739961.1 | hypothetical protein | - |
| HF085_RS05895 (1184057) | 1184057..1184404 | - | 348 | WP_114621444.1 | YopX family protein | - |
| HF085_RS05900 (1184401) | 1184401..1184793 | - | 393 | WP_249739962.1 | hypothetical protein | - |
| HF085_RS05905 (1184808) | 1184808..1185050 | - | 243 | WP_000131370.1 | SAV1978 family virulence-associated passenger protein | - |
| HF085_RS05910 (1185054) | 1185054..1185422 | - | 369 | WP_000101275.1 | SA1788 family PVL leukocidin-associated protein | - |
| HF085_RS05915 (1185435) | 1185435..1185839 | - | 405 | Protein_1141 | RusA family crossover junction endodeoxyribonuclease | - |
| HF085_RS05920 (1185848) | 1185848..1186066 | - | 219 | WP_000338530.1 | hypothetical protein | - |
| HF085_RS05925 (1186073) | 1186073..1186957 | - | 885 | WP_031833239.1 | DnaD domain protein | - |
| HF085_RS05930 (1186987) | 1186987..1187457 | - | 471 | WP_249739963.1 | single-stranded DNA-binding protein | - |
| HF085_RS05935 (1187458) | 1187458..1188075 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 1153392..1235724 | 82332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9289.16 Da Isoelectric Point: 3.8810
>T154222 WP_249739960.1 NZ_CP051479:c1183759-1183508 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQG
NDY
MNNREQIEQSVISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQG
NDY
Download Length: 252 bp
>T154222 NZ_CP067412:138652-138831 [Pseudomonas sp. HS6]
GTGAACAGCCGTTTTCTAATTGGCCAACTCGTCGCAGACGGTTGGTATCTGGTGCGGGTCAGGGGCAGTCATCATCACTT
CAAGCATCCGACCAAACCTGGTTTGGTCACAGTGCCTCACCCGAAGAAGGATCTGCTCAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGCTGCTTTGA
GTGAACAGCCGTTTTCTAATTGGCCAACTCGTCGCAGACGGTTGGTATCTGGTGCGGGTCAGGGGCAGTCATCATCACTT
CAAGCATCCGACCAAACCTGGTTTGGTCACAGTGCCTCACCCGAAGAAGGATCTGCTCAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGCTGCTTTGA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6482.32 Da Isoelectric Point: 4.2484
>AT154222 WP_168777632.1 NZ_CP051479:c1183518-1183345 [Staphylococcus aureus]
MTISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MTISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT154222 NZ_CP067412:138868-139275 [Pseudomonas sp. HS6]
ATGCTTTACCCAATTGCGATTTCAGTGGGTGATGAAGGACATGCCTGGGGAGTGGAGGTGCCGGATATTCCGGGCTGTTT
CTCCGCTGGAGATGATCTGGATGACGCGATGGCGATGGCCCGCGAAGCCATTGAAGGCCATTTCGAGATTCTGGCCGAAG
ACGGCTCGCCCATCCCGCCCGCCAACAAGGTCACGCTGCATGCCGCCAATCCAAAATACGCTGGCTGCACGTGGGCGTTG
GTGGACATCGATGTAACCAAATACCTGGGCAAAGCTCAGAAACTCAACATCACTTTGCCGGGCTATCTACTCAACCGTAT
CGATGAATACGTGTTGCACCATCCGGAGGAAAAAAGCCGCTCCGGGTTCTTGGCTTCAGCGGCGCTTAAGGTGTTGCAGC
AGGGTTGA
ATGCTTTACCCAATTGCGATTTCAGTGGGTGATGAAGGACATGCCTGGGGAGTGGAGGTGCCGGATATTCCGGGCTGTTT
CTCCGCTGGAGATGATCTGGATGACGCGATGGCGATGGCCCGCGAAGCCATTGAAGGCCATTTCGAGATTCTGGCCGAAG
ACGGCTCGCCCATCCCGCCCGCCAACAAGGTCACGCTGCATGCCGCCAATCCAAAATACGCTGGCTGCACGTGGGCGTTG
GTGGACATCGATGTAACCAAATACCTGGGCAAAGCTCAGAAACTCAACATCACTTTGCCGGGCTATCTACTCAACCGTAT
CGATGAATACGTGTTGCACCATCCGGAGGAAAAAAGCCGCTCCGGGTTCTTGGCTTCAGCGGCGCTTAAGGTGTTGCAGC
AGGGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|