Detailed information of TA system TA154218

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20168..20506
• Replicon: chromosome
• Accession: NZ_CP051479
• Organism: Staphylococcus aureus strain NGA76

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HF085_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20168..20344 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20332..20506 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF085_RS00085	17855..18007	+	153	WP_000654329.1	hypothetical protein	-
HF085_RS00090	18054..18341	+	288	WP_001040255.1	hypothetical protein	-
HF085_RS00095	18397..18771	+	375	WP_000340977.1	hypothetical protein	-
HF085_RS00100	19183..19965	+	783	WP_000034842.1	staphylococcal enterotoxin type P	-
HF085_RS00105	20168..20344	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20332..20506	-	175	-	-	Antitoxin
HF085_RS00115	20556..20810	+	255	WP_000611512.1	phage holin	-
HF085_RS00120	20822..21577	+	756	WP_000861038.1	CHAP domain-containing protein	-
HF085_RS00125	21768..22259	+	492	WP_000920038.1	staphylokinase	-
HF085_RS00130	22910..23245	+	336	Protein_26	SH3 domain-containing protein	-
HF085_RS00135	23756..24106	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
HF085_RS00140	24159..24419	-	261	WP_001791826.1	hypothetical protein	-
HF085_RS00145	24730..24909	-	180	WP_000669791.1	hypothetical protein	-
HF085_RS00150	25281..25478	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / scn / hlb / map	1..27916	27915

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T154218 WP_011447039.1 NZ_CP051479:20168-20344 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T154218 NZ_CP067400:35971-36282 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT154218 NZ_CP051479:c20506-20332 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin