Detailed information of TA system TA154196

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2518650..2518975
• Replicon: chromosome
• Accession: NZ_CP051465
• Organism: Bacillus subtilis subsp. subtilis strain UCMB5121

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: HC659_RS12875
• Protein ID: WP_004398662.1
• Coordinates: 2518650..2518829 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2518753..2518975 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC659_RS12865	2517876..2518013	-	138	WP_021480099.1	hypothetical protein	-
HC659_RS12870	2518055..2518504	-	450	WP_032722171.1	phage portal protein	-
HC659_RS12875	2518650..2518829	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2518753..2518975	-	223	NuclAT_0	-	Antitoxin
-	2518753..2518975	-	223	NuclAT_0	-	Antitoxin
-	2518753..2518975	-	223	NuclAT_0	-	Antitoxin
-	2518753..2518975	-	223	NuclAT_0	-	Antitoxin
HC659_RS12880	2519209..2519298	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
HC659_RS12885	2519552..2519995	-	444	WP_003229930.1	phage tail tube protein	-
HC659_RS12890	2519998..2521398	-	1401	WP_003229929.1	phage tail sheath family protein	-
HC659_RS12895	2521399..2521590	-	192	WP_010886574.1	hypothetical protein	-
HC659_RS12900	2521587..2522024	-	438	WP_003229927.1	hypothetical protein	-
HC659_RS12905	2522037..2522540	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
HC659_RS12910	2522537..2522899	-	363	WP_003229925.1	YqbH/XkdH family protein	-
HC659_RS12915	2522896..2523291	-	396	WP_004398566.1	DUF3199 family protein	-
HC659_RS12920	2523295..2523606	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2488185..2543514	55329

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T154196 WP_004398662.1 NZ_CP051465:2518650-2518829 [Bacillus subtilis subsp. subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T154196 NZ_CP067398:c86972-86574 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin

Nucleotide

• Length: 223 bp

>AT154196 NZ_CP051465:c2518975-2518753 [Bacillus subtilis subsp. subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin