Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3887989..3888788 Replicon chromosome
Accession NZ_CP051430
Organism Escherichia sp. SCLE84

Toxin (Protein)


Gene name yhaV Uniprot ID A0A6H2GMC5
Locus tag HGD79_RS18875 Protein ID WP_000347279.1
Coordinates 3887989..3888453 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag HGD79_RS18880 Protein ID WP_001307405.1
Coordinates 3888453..3888788 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD79_RS18845 3882990..3883424 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
HGD79_RS18850 3883442..3884320 - 879 WP_001298758.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HGD79_RS18855 3884310..3885089 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HGD79_RS18860 3885100..3885573 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HGD79_RS18865 3885596..3886876 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
HGD79_RS18870 3887125..3887934 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HGD79_RS18875 3887989..3888453 - 465 WP_000347279.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HGD79_RS18880 3888453..3888788 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HGD79_RS18885 3888937..3890508 - 1572 WP_024243610.1 galactarate dehydratase -
HGD79_RS18890 3890883..3892217 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HGD79_RS18895 3892233..3893003 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3887989..3900723 12734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17869.24 Da        Isoelectric Point: 9.4947

>T154111 WP_000347279.1 NZ_CP051430:c3888453-3887989 [Escherichia sp. SCLE84]
MDFPQRVNGWVLYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESFTQETEENH

Download         Length: 465 bp

>T154111 NZ_CP067342:2393958-2394245 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT154111 WP_001307405.1 NZ_CP051430:c3888788-3888453 [Escherichia sp. SCLE84]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT154111 NZ_CP067342:2393719-2393958 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GMC5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References