Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 114011..114513 Replicon chromosome
Accession NZ_CP051430
Organism Escherichia sp. SCLE84

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag HGD79_RS00530 Protein ID WP_000767829.1
Coordinates 114259..114513 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HGD79_RS00525 Protein ID WP_001259255.1
Coordinates 114011..114262 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD79_RS00500 109189..110256 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HGD79_RS00505 110256..111326 - 1071 WP_000108972.1 histidinol-phosphate transaminase -
HGD79_RS00510 111323..112627 - 1305 WP_001386882.1 histidinol dehydrogenase -
HGD79_RS00515 112633..113532 - 900 WP_000131756.1 ATP phosphoribosyltransferase -
HGD79_RS00520 113678..113728 - 51 WP_001364200.1 his operon leader peptide -
HGD79_RS00525 114011..114262 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HGD79_RS00530 114259..114513 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HGD79_RS00535 114596..115420 + 825 WP_000754763.1 SDR family oxidoreductase -
HGD79_RS00540 115466..116395 + 930 WP_168848243.1 LysR family transcriptional regulator -
HGD79_RS00545 116610..116672 + 63 WP_010723108.1 membrane protein YoeI -
HGD79_RS00550 116662..118020 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HGD79_RS00555 118199..119257 + 1059 WP_023568741.1 transport protein YeeE -
HGD79_RS00560 119271..119498 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T154092 WP_000767829.1 NZ_CP051430:114259-114513 [Escherichia sp. SCLE84]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T154092 NZ_CP067312:250465-250773 [Escherichia coli]
ATGCAATATACCGTTTACCGCAATCCCGGCAACAGCCAGGCATACCCTTACCTGCTGGATATACAGAGCGACATCATTGG
CGAGTTAAATACCCGCCTGGTGATCCCCCTTCATCGGCTTAAAAAAGGAGCCTCGGCCCCGGTTGCGCGATTAACTCCGG
TCATACAGGTGGAAGGGAATGACGTTATCCTGATGACGCATGAAATGGCTTCAGTCCGCGTGAAGCAGCTCGGTCAGGCG
GTCATGGACGCATCTCCGTTCCGGCACACTATCAAAAGTGCGGTGGACTTCCTGCTGGATGGTTTCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT154092 WP_001259255.1 NZ_CP051430:114011-114262 [Escherichia sp. SCLE84]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT154092 NZ_CP067312:250223-250462 [Escherichia coli]
ATGCAGGCTACAGCTGCTCGCCAGAAAAAAACCGTCAGTGTCACCCTTGAGCCAATGCTCGTACAGCAGGCAAAAGACGC
TGGGATTAACTTGTCCGCCACGCTGGCAGAAGCGCTTCAGAGCAAACTGAAGGCCAGTGCAGCGGAAGAATGGAAACGAC
AGAATCGTGCTGGTATTCAGGAGTTGAACCGCATCACTGAAGAGCATGGGTTACTGTCTGACGAATACAGGACGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References