Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 142018..142675 | Replicon | plasmid p20723-1 |
| Accession | NZ_CP051426 | ||
| Organism | Salmonella enterica subsp. enterica serovar Uganda strain CVM 20723 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | HFQ25_RS24450 | Protein ID | WP_000270043.1 |
| Coordinates | 142018..142368 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HFQ25_RS24455 | Protein ID | WP_000124640.1 |
| Coordinates | 142373..142675 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFQ25_RS24405 | 137329..137508 | + | 180 | Protein_153 | helix-turn-helix transcriptional regulator | - |
| HFQ25_RS24410 | 137573..138277 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HFQ25_RS24415 | 138492..138989 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| HFQ25_RS24420 | 138992..139480 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| HFQ25_RS24425 | 139577..139912 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| HFQ25_RS24430 | 139927..140397 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| HFQ25_RS24435 | 140390..140761 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| HFQ25_RS24440 | 140772..140966 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| HFQ25_RS24445 | 141307..141855 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| HFQ25_RS24450 | 142018..142368 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HFQ25_RS24455 | 142373..142675 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| HFQ25_RS24460 | 142702..142995 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| HFQ25_RS24465 | 143083..143355 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| HFQ25_RS24470 | 143413..143940 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| HFQ25_RS24475 | 144171..145028 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| HFQ25_RS24480 | 145015..145245 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| HFQ25_RS24485 | 145245..145763 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| HFQ25_RS24490 | 145760..146206 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| HFQ25_RS24495 | 146206..146565 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| HFQ25_RS24500 | 146622..147050 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..188725 | 188725 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T154057 WP_000270043.1 NZ_CP051426:142018-142368 [Salmonella enterica subsp. enterica serovar Uganda]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 351 bp
>T154057 NZ_CP067307:c2497160-2496873 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT154057 WP_000124640.1 NZ_CP051426:142373-142675 [Salmonella enterica subsp. enterica serovar Uganda]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
Download Length: 303 bp
>AT154057 NZ_CP067307:c2497399-2497160 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|