Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 95052..95709 | Replicon | plasmid p21794 |
| Accession | NZ_CP051403 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain CVM 21974 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | HFQ69_RS24255 | Protein ID | WP_000270043.1 |
| Coordinates | 95359..95709 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HFQ69_RS24250 | Protein ID | WP_000124640.1 |
| Coordinates | 95052..95354 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFQ69_RS24205 | 90677..91105 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| HFQ69_RS24210 | 91162..91521 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| HFQ69_RS24215 | 91521..91967 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| HFQ69_RS24220 | 91964..92482 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| HFQ69_RS24225 | 92482..92712 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| HFQ69_RS24230 | 92699..93556 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| HFQ69_RS24235 | 93787..94314 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| HFQ69_RS24240 | 94372..94644 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| HFQ69_RS24245 | 94732..95025 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| HFQ69_RS24250 | 95052..95354 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| HFQ69_RS24255 | 95359..95709 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HFQ69_RS24260 | 95872..96420 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| HFQ69_RS24265 | 96761..96955 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| HFQ69_RS24270 | 96966..97337 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| HFQ69_RS24275 | 97330..97800 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| HFQ69_RS24280 | 97815..98150 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| HFQ69_RS24285 | 98247..98735 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| HFQ69_RS24290 | 98738..99235 | + | 498 | WP_000062185.1 | hypothetical protein | - |
| HFQ69_RS24295 | 99450..100154 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HFQ69_RS24300 | 100461..100640 | + | 180 | Protein_125 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..102040 | 102040 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T154048 WP_000270043.1 NZ_CP051403:c95709-95359 [Salmonella enterica subsp. enterica serovar Agona]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T154048 NZ_CP067307:c926745-926467 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT154048 WP_000124640.1 NZ_CP051403:c95354-95052 [Salmonella enterica subsp. enterica serovar Agona]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
Download Length: 303 bp
>AT154048 NZ_CP067307:c927008-926748 [Escherichia coli]
ATGGCTGCAAATGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCAAATGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|