Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 136750..137407 | Replicon | plasmid p22436-1 |
| Accession | NZ_CP051400 | ||
| Organism | Salmonella enterica subsp. enterica serovar Uganda strain CVM 22436 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | HFQ88_RS24340 | Protein ID | WP_000270043.1 |
| Coordinates | 136750..137100 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HFQ88_RS24345 | Protein ID | WP_000124640.1 |
| Coordinates | 137105..137407 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFQ88_RS24295 | 132061..132240 | + | 180 | Protein_147 | helix-turn-helix transcriptional regulator | - |
| HFQ88_RS24300 | 132305..133009 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HFQ88_RS24305 | 133224..133721 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| HFQ88_RS24310 | 133724..134212 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| HFQ88_RS24315 | 134309..134644 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| HFQ88_RS24320 | 134659..135129 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| HFQ88_RS24325 | 135122..135493 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| HFQ88_RS24330 | 135504..135698 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| HFQ88_RS24335 | 136039..136587 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| HFQ88_RS24340 | 136750..137100 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HFQ88_RS24345 | 137105..137407 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| HFQ88_RS24350 | 137434..137727 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| HFQ88_RS24355 | 137815..138087 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| HFQ88_RS24360 | 138145..138672 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| HFQ88_RS24365 | 138903..139760 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| HFQ88_RS24370 | 139747..139977 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| HFQ88_RS24375 | 139977..140495 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| HFQ88_RS24380 | 140492..140938 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| HFQ88_RS24385 | 140938..141297 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| HFQ88_RS24390 | 141354..141782 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..183507 | 183507 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T154047 WP_000270043.1 NZ_CP051400:136750-137100 [Salmonella enterica subsp. enterica serovar Uganda]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 351 bp
>T154047 NZ_CP067307:696349-696663 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTATCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTATCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT154047 WP_000124640.1 NZ_CP051400:137105-137407 [Salmonella enterica subsp. enterica serovar Uganda]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
Download Length: 303 bp
>AT154047 NZ_CP067307:696113-696346 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|