Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 151165..151822 | Replicon | plasmid p22448 |
| Accession | NZ_CP051395 | ||
| Organism | Salmonella enterica subsp. enterica serovar Anatum strain CVM 22448 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | HFQ94_RS23515 | Protein ID | WP_000270043.1 |
| Coordinates | 151165..151515 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HFQ94_RS23520 | Protein ID | WP_000124640.1 |
| Coordinates | 151520..151822 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFQ94_RS23470 | 146476..146655 | + | 180 | Protein_163 | helix-turn-helix transcriptional regulator | - |
| HFQ94_RS23475 | 146720..147424 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HFQ94_RS23480 | 147639..148136 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| HFQ94_RS23485 | 148139..148627 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| HFQ94_RS23490 | 148724..149059 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| HFQ94_RS23495 | 149074..149544 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| HFQ94_RS23500 | 149537..149908 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| HFQ94_RS23505 | 149919..150113 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| HFQ94_RS23510 | 150454..151002 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| HFQ94_RS23515 | 151165..151515 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HFQ94_RS23520 | 151520..151822 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| HFQ94_RS23525 | 151849..152142 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| HFQ94_RS23530 | 152230..152502 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| HFQ94_RS23535 | 152560..153087 | - | 528 | WP_063177097.1 | thermonuclease family protein | - |
| HFQ94_RS23540 | 153318..154175 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| HFQ94_RS23545 | 154162..154392 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| HFQ94_RS23550 | 154392..154910 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| HFQ94_RS23555 | 154907..155353 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| HFQ94_RS23560 | 155353..155712 | - | 360 | WP_000422768.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..155923 | 155923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T154043 WP_000270043.1 NZ_CP051395:151165-151515 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 351 bp
>T154043 NZ_CP067304:46160-46558 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT154043 WP_000124640.1 NZ_CP051395:151520-151822 [Salmonella enterica subsp. enterica serovar Anatum]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
Download Length: 303 bp
>AT154043 NZ_CP067304:45933-46160 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|