Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 58282..58939 | Replicon | plasmid p20723-2 |
| Accession | NZ_CP051373 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport strain CVM 24374 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | HFS12_RS22825 | Protein ID | WP_000270043.1 |
| Coordinates | 58282..58632 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HFS12_RS22830 | Protein ID | WP_000124640.1 |
| Coordinates | 58637..58939 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFS12_RS22780 | 53593..53772 | + | 180 | Protein_59 | helix-turn-helix transcriptional regulator | - |
| HFS12_RS22785 | 53837..54541 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HFS12_RS22790 | 54756..55253 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| HFS12_RS22795 | 55256..55744 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| HFS12_RS22800 | 55841..56176 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| HFS12_RS22805 | 56191..56661 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| HFS12_RS22810 | 56654..57025 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| HFS12_RS22815 | 57036..57230 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| HFS12_RS22820 | 57571..58119 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| HFS12_RS22825 | 58282..58632 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HFS12_RS22830 | 58637..58939 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| HFS12_RS22835 | 58966..59259 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| HFS12_RS22840 | 59347..59619 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| HFS12_RS22845 | 59677..60204 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| HFS12_RS22850 | 60435..61292 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| HFS12_RS22855 | 61279..61509 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| HFS12_RS22860 | 61509..62027 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| HFS12_RS22865 | 62024..62470 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| HFS12_RS22870 | 62470..62829 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| HFS12_RS22875 | 62886..63314 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..122954 | 122954 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T154031 WP_000270043.1 NZ_CP051373:58282-58632 [Salmonella enterica subsp. enterica serovar Newport]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 351 bp
>T154031 NZ_CP067303:c2151539-2151252 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT154031 WP_000124640.1 NZ_CP051373:58637-58939 [Salmonella enterica subsp. enterica serovar Newport]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
Download Length: 303 bp
>AT154031 NZ_CP067303:c2151778-2151539 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|