Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1782261..1782921 Replicon chromosome
Accession NZ_CP051368
Organism Salmonella enterica subsp. houtenae serovar 43:z4 strain CVM 24399

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HFS24_RS08370 Protein ID WP_001664230.1
Coordinates 1782261..1782614 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HFS24_RS08375 Protein ID WP_219827277.1
Coordinates 1782619..1782921 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS24_RS08360 (1777949) 1777949..1780849 + 2901 WP_219827275.1 RHS repeat domain-containing protein -
HFS24_RS23320 (1781223) 1781223..1781545 + 323 Protein_1650 hypothetical protein -
HFS24_RS08365 (1781542) 1781542..1781763 + 222 WP_219827276.1 helix-turn-helix transcriptional regulator -
HFS24_RS08370 (1782261) 1782261..1782614 + 354 WP_001664230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HFS24_RS08375 (1782619) 1782619..1782921 + 303 WP_219827277.1 XRE family transcriptional regulator Antitoxin
HFS24_RS08380 (1783426) 1783426..1784065 + 640 Protein_1654 integrase domain-containing protein -
HFS24_RS08385 (1784592) 1784592..1785841 - 1250 Protein_1655 tyrosine-type recombinase/integrase -
HFS24_RS08390 (1786141) 1786141..1786848 - 708 WP_219827278.1 hypothetical protein -
HFS24_RS08395 (1786853) 1786853..1787482 - 630 WP_219827279.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - wza / gmd / wcaG / manB / galF / gmd / wcaG / manB / gnd / ugd / hcp2/tssD2 1701119..1835991 134872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13445.32 Da        Isoelectric Point: 8.0068

>T154013 WP_001664230.1 NZ_CP051368:1782261-1782614 [Salmonella enterica subsp. houtenae serovar 43:z4]
VWTITTTDMFDHWFSSLNDTDRASVLAALLVLREKGPGLSRPYADTLRGSRFSNMKELRIQSRGDPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNIIKEKE

Download         Length: 354 bp

>T154013 NZ_CP067299:c3574080-3573673 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11131.01 Da        Isoelectric Point: 5.7316

>AT154013 WP_219827277.1 NZ_CP051368:1782619-1782921 [Salmonella enterica subsp. houtenae serovar 43:z4]
MGRMLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQMLGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT154013 NZ_CP067299:c3574327-3574061 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References