Detailed information of TA system TA154003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 124461..125118
• Replicon: plasmid p28336
• Accession: NZ_CP051357
• Organism: Salmonella enterica subsp. enterica serovar Agona strain CVM 28336

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: HFS76_RS24715
• Protein ID: WP_000270043.1
• Coordinates: 124768..125118 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HFS76_RS24710
• Protein ID: WP_000124640.1
• Coordinates: 124461..124763 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFS76_RS24665	120086..120514	+	429	WP_000591074.1	hypothetical protein	-
HFS76_RS24670	120571..120930	+	360	WP_000422768.1	hypothetical protein	-
HFS76_RS24675	120930..121376	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
HFS76_RS24680	121373..121891	+	519	WP_000210756.1	nitrite reductase	-
HFS76_RS24685	121891..122121	+	231	WP_000972663.1	hypothetical protein	-
HFS76_RS24690	122108..122965	+	858	WP_001167032.1	hypothetical protein	-
HFS76_RS24695	123196..123723	+	528	WP_001236377.1	thermonuclease family protein	-
HFS76_RS24700	123781..124053	+	273	WP_001043047.1	HU family DNA-binding protein	-
HFS76_RS24705	124141..124434	+	294	WP_001239997.1	chromosome segregation protein ParM	-
HFS76_RS24710	124461..124763	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
HFS76_RS24715	124768..125118	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HFS76_RS24720	125281..125829	+	549	WP_001061574.1	transcriptional regulator	-
HFS76_RS24725	126170..126364	+	195	WP_000343597.1	hypothetical protein	-
HFS76_RS24730	126375..126746	+	372	WP_000516916.1	hypothetical protein	-
HFS76_RS24735	126739..127209	+	471	WP_001281821.1	hypothetical protein	-
HFS76_RS24740	127224..127559	-	336	WP_000683476.1	hypothetical protein	-
HFS76_RS24745	127656..128144	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
HFS76_RS24750	128147..128644	+	498	WP_000062185.1	hypothetical protein	-
HFS76_RS24755	128971..129675	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
HFS76_RS24760	129740..129919	-	180	Protein_147	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..161620	161620

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T154003 WP_000270043.1 NZ_CP051357:c125118-124768 [Salmonella enterica subsp. enterica serovar Agona]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T154003 NZ_CP067299:c1843709-1843602 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT154003 WP_000124640.1 NZ_CP051357:c124763-124461 [Salmonella enterica subsp. enterica serovar Agona]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT154003 NZ_CP067299:1843756-1843822 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9