Detailed information of TA system TA153996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 98844..99501
• Replicon: plasmid p34530-1
• Accession: NZ_CP051319
• Organism: Salmonella enterica subsp. enterica serovar Newport strain CVM 34530

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: HFT88_RS24925
• Protein ID: WP_000270043.1
• Coordinates: 99151..99501 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HFT88_RS24920
• Protein ID: WP_000124640.1
• Coordinates: 98844..99146 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HFT88_RS24875	94469..94897	+	429	WP_000591074.1	hypothetical protein	-
HFT88_RS24880	94954..95313	+	360	WP_000422768.1	hypothetical protein	-
HFT88_RS24885	95313..95759	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
HFT88_RS24890	95756..96274	+	519	WP_000210756.1	nitrite reductase	-
HFT88_RS24895	96274..96504	+	231	WP_000972663.1	hypothetical protein	-
HFT88_RS24900	96491..97348	+	858	WP_001167032.1	hypothetical protein	-
HFT88_RS24905	97579..98106	+	528	WP_001236377.1	thermonuclease family protein	-
HFT88_RS24910	98164..98436	+	273	WP_001043047.1	HU family DNA-binding protein	-
HFT88_RS24915	98524..98817	+	294	WP_001239997.1	chromosome segregation protein ParM	-
HFT88_RS24920	98844..99146	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
HFT88_RS24925	99151..99501	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HFT88_RS24930	99664..100212	+	549	WP_001061574.1	transcriptional regulator	-
HFT88_RS24935	100553..100747	+	195	WP_000343597.1	hypothetical protein	-
HFT88_RS24940	100758..101129	+	372	WP_000516916.1	hypothetical protein	-
HFT88_RS24945	101122..101592	+	471	WP_001281821.1	hypothetical protein	-
HFT88_RS24950	101607..101942	-	336	WP_000683476.1	hypothetical protein	-
HFT88_RS24955	102039..102527	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
HFT88_RS24960	102530..103027	+	498	WP_000062185.1	hypothetical protein	-
HFT88_RS24965	103242..103946	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
HFT88_RS24970	104011..104190	-	180	Protein_125	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..170814	170814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T153996 WP_000270043.1 NZ_CP051319:c99501-99151 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T153996 NZ_CP067299:267221-267394 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT153996 WP_000124640.1 NZ_CP051319:c99146-98844 [Salmonella enterica subsp. enterica serovar Newport]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT153996 NZ_CP067299:266897-267193 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9