Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 37323..37980 | Replicon | plasmid p35189-1 |
| Accession | NZ_CP051308 | ||
| Organism | Salmonella enterica subsp. enterica serovar Reading strain CVM 35189 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | HFU35_RS24000 | Protein ID | WP_000270043.1 |
| Coordinates | 37323..37673 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HFU35_RS24005 | Protein ID | WP_000124640.1 |
| Coordinates | 37678..37980 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HFU35_RS23955 | 32634..32813 | + | 180 | Protein_32 | helix-turn-helix transcriptional regulator | - |
| HFU35_RS23960 | 32878..33582 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| HFU35_RS23965 | 33797..34294 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| HFU35_RS23970 | 34297..34785 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| HFU35_RS23975 | 34882..35217 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| HFU35_RS23980 | 35232..35702 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| HFU35_RS23985 | 35695..36066 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| HFU35_RS23990 | 36077..36271 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| HFU35_RS23995 | 36612..37160 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| HFU35_RS24000 | 37323..37673 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HFU35_RS24005 | 37678..37980 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| HFU35_RS24010 | 38007..38300 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| HFU35_RS24015 | 38388..38660 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| HFU35_RS24020 | 38718..39245 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| HFU35_RS24025 | 39476..40333 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| HFU35_RS24030 | 40320..40550 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| HFU35_RS24035 | 40550..41068 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| HFU35_RS24040 | 41065..41511 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| HFU35_RS24045 | 41511..41870 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| HFU35_RS24050 | 41927..42355 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..154276 | 154276 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 15014.38 Da Isoelectric Point: 12.8644
>T153989 WP_000270043.1 NZ_CP051308:37323-37673 [Salmonella enterica subsp. enterica serovar Reading]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
Download Length: 351 bp
>T153989 NZ_CP067265:3611761-3612075 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 12963.60 Da Isoelectric Point: 12.8000
>AT153989 WP_000124640.1 NZ_CP051308:37678-37980 [Salmonella enterica subsp. enterica serovar Reading]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK
Download Length: 303 bp
>AT153989 NZ_CP067265:3612072-3612488 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|