Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 722281..722910 Replicon chromosome
Accession NZ_CP051305
Organism Treponema sp. OMZ 798

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4O07_RS03410 Protein ID WP_253678581.1
Coordinates 722602..722910 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4O07_RS03405 Protein ID WP_253687396.1
Coordinates 722281..722592 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O07_RS03370 (E4O07_03350) 717387..717725 + 339 WP_253687387.1 hypothetical protein -
E4O07_RS03375 (E4O07_03355) 717763..718206 - 444 WP_253678575.1 SUF system NifU family Fe-S cluster assembly protein -
E4O07_RS03380 (E4O07_03360) 718233..719435 - 1203 WP_253687388.1 SufS family cysteine desulfurase -
E4O07_RS03385 (E4O07_03365) 719657..719944 + 288 WP_253687389.1 putative addiction module antidote protein -
E4O07_RS03390 (E4O07_03370) 720072..720335 + 264 WP_253687390.1 hypothetical protein -
E4O07_RS03395 (E4O07_03375) 720304..720660 + 357 WP_253687392.1 helix-turn-helix transcriptional regulator -
E4O07_RS03400 (E4O07_03380) 720973..722154 + 1182 WP_253687394.1 formylglycine-generating enzyme family protein -
E4O07_RS03405 (E4O07_03385) 722281..722592 - 312 WP_253687396.1 NadS family protein Antitoxin
E4O07_RS03410 (E4O07_03390) 722602..722910 - 309 WP_253678581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4O07_RS03420 (E4O07_03400) 723253..724845 - 1593 WP_253687398.1 peptide ABC transporter substrate-binding protein -
E4O07_RS03425 (E4O07_03405) 724919..726322 - 1404 WP_253687400.1 hypothetical protein -
E4O07_RS03430 (E4O07_03410) 726432..726725 + 294 WP_253687401.1 CRISPR-associated protein Cas2 -
E4O07_RS03435 (E4O07_03415) 726730..727852 + 1123 WP_253687403.1 peptide chain release factor 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11735.97 Da        Isoelectric Point: 10.5337

>T153987 WP_253678581.1 NZ_CP051305:c722910-722602 [Treponema sp. OMZ 798]
MKIIETPVFTKQINKLLDEDTYKQFKEYLVCNPLKGKLIKGGAGIRKIRWGKKNTGKSGGVRIIYFIKTETKIYLLFAYS
KSDAENITKKQINMLASFIKDL

Download         Length: 309 bp

>T153987 NZ_CP067265:3128183-3128290 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11648.56 Da        Isoelectric Point: 9.6545

>AT153987 WP_253687396.1 NZ_CP051305:c722592-722281 [Treponema sp. OMZ 798]
MFKRKKMSDEMFTELLQSVKEAVLIEKGEIPPSRVFEIEPLDIAKIRDKTNKTQEEFAAMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLKGG

Download         Length: 312 bp

>AT153987 NZ_CP067265:c3128135-3128069 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References