Detailed information of TA system TA153984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1730817..1731443
• Replicon: chromosome
• Accession: NZ_CP051304
• Organism: Treponema denticola strain CD-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q73NN6
• Locus tag: E4N79_RS08025
• Protein ID: WP_002677634.1
• Coordinates: 1730817..1731125 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E4N79_RS08030
• Protein ID: WP_002689588.1
• Coordinates: 1731135..1731443 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N79_RS07995 (E4N79_08000)	1726770..1727108	+	339	WP_002670686.1	anti-sigma factor antagonist	-
E4N79_RS08000 (E4N79_08005)	1727125..1727667	+	543	WP_253688339.1	ATP-binding protein	-
E4N79_RS08005 (E4N79_08010)	1727682..1728503	-	822	WP_253688340.1	hypothetical protein	-
E4N79_RS08010 (E4N79_08015)	1728484..1729104	-	621	WP_002671735.1	hypothetical protein	-
E4N79_RS08015 (E4N79_08020)	1729220..1730599	+	1380	WP_002670676.1	tyrosine phenol-lyase	-
E4N79_RS08020 (E4N79_08025)	1730640..1730789	-	150	WP_253688341.1	hypothetical protein	-
E4N79_RS08025 (E4N79_08030)	1730817..1731125	+	309	WP_002677634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4N79_RS08030 (E4N79_08035)	1731135..1731443	+	309	WP_002689588.1	NadS family protein	Antitoxin
E4N79_RS08035 (E4N79_08040)	1731576..1732247	+	672	WP_253688342.1	TetR/AcrR family transcriptional regulator	-
E4N79_RS08040 (E4N79_08045)	1732336..1732752	+	417	WP_245522456.1	SRPBCC family protein	-
E4N79_RS08045 (E4N79_08050)	1732876..1733505	-	630	WP_253688343.1	adenylate kinase	-
E4N79_RS08050 (E4N79_08055)	1733564..1734793	-	1230	WP_002670666.1	cation:dicarboxylase symporter family transporter	-
E4N79_RS08055 (E4N79_08060)	1734832..1736151	-	1320	WP_253688344.1	leucine-rich repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-86)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11736.96 Da
• Isoelectric Point: 10.6864

>T153984 WP_002677634.1 NZ_CP051304:1730817-1731125 [Treponema denticola]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Nucleotide

• Length: 309 bp

>T153984 NZ_CP067265:c1948023-1947625 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11563.46 Da
• Isoelectric Point: 9.6884

>AT153984 WP_002689588.1 NZ_CP051304:1731135-1731443 [Treponema denticola]
MFKRKKMSDEMFAELLQSVKEAVLIEKGEIPPSRIFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Nucleotide

• Length: 309 bp

>AT153984 NZ_CP067265:c1948319-1948026 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: Q73NN6