Detailed information of TA system TA153979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1677533..1678159
• Replicon: chromosome
• Accession: NZ_CP051303
• Organism: Treponema denticola strain OT2B

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q73NN6
• Locus tag: E4N91_RS07685
• Protein ID: WP_002677634.1
• Coordinates: 1677533..1677841 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: E4N91_RS07690
• Protein ID: WP_002689588.1
• Coordinates: 1677851..1678159 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N91_RS07660 (E4N91_07665)	1673486..1673824	+	339	WP_002670686.1	anti-sigma factor antagonist	-
E4N91_RS07665 (E4N91_07670)	1673841..1674383	+	543	WP_002670683.1	ATP-binding protein	-
E4N91_RS07670 (E4N91_07675)	1674398..1675219	-	822	WP_253703795.1	hypothetical protein	-
E4N91_RS07675 (E4N91_07680)	1675200..1675820	-	621	WP_002671735.1	hypothetical protein	-
E4N91_RS07680 (E4N91_07685)	1675936..1677315	+	1380	WP_002689587.1	tyrosine phenol-lyase	-
E4N91_RS07685 (E4N91_07690)	1677533..1677841	+	309	WP_002677634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4N91_RS07690 (E4N91_07695)	1677851..1678159	+	309	WP_002689588.1	NadS family protein	Antitoxin
E4N91_RS07695 (E4N91_07700)	1678292..1678963	+	672	WP_002670670.1	TetR/AcrR family transcriptional regulator	-
E4N91_RS07700 (E4N91_07705)	1679052..1679468	+	417	WP_253703797.1	SRPBCC family protein	-
E4N91_RS07705 (E4N91_07710)	1679600..1680229	-	630	WP_253701652.1	adenylate kinase	-
E4N91_RS07710 (E4N91_07715)	1680287..1681516	-	1230	WP_002670666.1	cation:dicarboxylase symporter family transporter	-
E4N91_RS07715 (E4N91_07720)	1681555..1682874	-	1320	WP_253703799.1	leucine-rich repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-86)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11736.96 Da
• Isoelectric Point: 10.6864

>T153979 WP_002677634.1 NZ_CP051303:1677533-1677841 [Treponema denticola]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Nucleotide

• Length: 309 bp

>T153979 NZ_CP067265:c725003-724827 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11563.46 Da
• Isoelectric Point: 9.6884

>AT153979 WP_002689588.1 NZ_CP051303:1677851-1678159 [Treponema denticola]
MFKRKKMSDEMFAELLQSVKEAVLIEKGEIPPSRIFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Nucleotide

• Length: 309 bp

>AT153979 NZ_CP067265:c724781-724365 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: Q73NN6