Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2290399..2291028 Replicon chromosome
Accession NZ_CP051301
Organism Treponema sp. OMZ 799

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4O04_RS10580 Protein ID WP_253707852.1
Coordinates 2290399..2290707 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4O04_RS10585 Protein ID WP_253687396.1
Coordinates 2290717..2291028 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O04_RS10560 (E4O04_10525) 2286584..2286877 - 294 WP_253687401.1 CRISPR-associated protein Cas2 -
E4O04_RS10565 (E4O04_10530) 2286987..2288390 + 1404 WP_253707847.1 hypothetical protein -
E4O04_RS10570 (E4O04_10535) 2288464..2290056 + 1593 WP_253707849.1 peptide ABC transporter substrate-binding protein -
E4O04_RS10580 (E4O04_10545) 2290399..2290707 + 309 WP_253707852.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4O04_RS10585 (E4O04_10550) 2290717..2291028 + 312 WP_253687396.1 NadS family protein Antitoxin
E4O04_RS10590 (E4O04_10555) 2291155..2292336 - 1182 WP_253707855.1 formylglycine-generating enzyme family protein -
E4O04_RS10595 (E4O04_10560) 2292648..2293004 - 357 WP_253687392.1 helix-turn-helix transcriptional regulator -
E4O04_RS10600 (E4O04_10565) 2292973..2293236 - 264 WP_253687390.1 hypothetical protein -
E4O04_RS10605 (E4O04_10570) 2293364..2293651 - 288 WP_253687389.1 putative addiction module antidote protein -
E4O04_RS10610 (E4O04_10575) 2293873..2295075 + 1203 WP_253707858.1 SufS family cysteine desulfurase -
E4O04_RS10615 (E4O04_10580) 2295102..2295545 + 444 WP_253707861.1 SUF system NifU family Fe-S cluster assembly protein -
E4O04_RS10620 (E4O04_10585) 2295583..2295921 - 339 WP_253707864.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11736.02 Da        Isoelectric Point: 10.5858

>T153973 WP_253707852.1 NZ_CP051301:2290399-2290707 [Treponema sp. OMZ 799]
MKIIETPVFTKQINKLLDEDTYKKFKEYLVCNPLKGKLIKGGAGIRKIRWGKKNTGKSGGVRIIYFIKTETKIYLLFAYS
KSDAENITKKQINMLASFIKDL

Download         Length: 309 bp

>T153973 NZ_CP067261:c5079532-5078615 [Klebsiella variicola]
ATGGATATACAGGCGCCCTATTATCGGCAGGTTGCTCTGTTAATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGATTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAACGATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCTAATCTGCAACAACAG
GCAGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAGATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAA
GATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACCACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAGGAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCCTCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCC
TGTTTCACGCAACAGGATATCGATTTTTTGCTGTCATTTAAACGAGGCGAACCAGACTGGCGGTTAGCGCCGGAAACACG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCGTTAG
ATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11648.56 Da        Isoelectric Point: 9.6545

>AT153973 WP_253687396.1 NZ_CP051301:2290717-2291028 [Treponema sp. OMZ 799]
MFKRKKMSDEMFTELLQSVKEAVLIEKGEIPPSRVFEIEPLDIAKIRDKTNKTQEEFAAMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLKGG

Download         Length: 312 bp

>AT153973 NZ_CP067261:c5080296-5079538 [Klebsiella variicola]
ATGCCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCGGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGCAACGGCGTATACGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTAGCCGCTCCGGTGTATGTCGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGTCGTTCACACTATCTACAGCTCAAACAAAACCAGTGCTGGTTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGCAAAAACTGCCGGTGCTGGATGATA
AATACCGCGTAACGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGTGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TATCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References