Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1029663..1030251 Replicon chromosome
Accession NZ_CP051291
Organism Helicobacter pylori strain ASHA-002

Toxin (Protein)


Gene name TfiT Uniprot ID J0ILK7
Locus tag HGI44_RS04980 Protein ID WP_000921935.1
Coordinates 1029663..1029944 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID G2MA82
Locus tag HGI44_RS04985 Protein ID WP_000065286.1
Coordinates 1029937..1030251 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI44_RS04945 1024856..1025139 + 284 Protein_964 hypothetical protein -
HGI44_RS04950 1025121..1025422 + 302 Protein_965 hypothetical protein -
HGI44_RS04955 1025422..1026363 + 942 Protein_966 Flp pilus assembly complex ATPase component TadA -
HGI44_RS04960 1026360..1026815 + 456 WP_202135313.1 mobilization protein -
HGI44_RS04965 1026812..1027102 + 291 WP_202135314.1 hypothetical protein -
HGI44_RS04970 1027103..1027660 + 558 WP_202135315.1 hypothetical protein -
HGI44_RS04975 1027661..1029388 + 1728 WP_202136117.1 type IV secretory system conjugative DNA transfer family protein -
HGI44_RS04980 1029663..1029944 - 282 WP_000921935.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HGI44_RS04985 1029937..1030251 - 315 WP_000065286.1 hypothetical protein Antitoxin
HGI44_RS04990 1030543..1030698 + 156 WP_202135317.1 relaxase -
HGI44_RS04995 1030715..1031341 + 627 WP_202135318.1 hypothetical protein -
HGI44_RS05000 1031398..1032327 - 930 WP_202135319.1 hypothetical protein -
HGI44_RS05005 1032561..1033538 + 978 WP_202135320.1 HipA domain-containing protein -
HGI44_RS05010 1033710..1034084 + 375 Protein_977 CAAX protease -
HGI44_RS05015 1034106..1034393 + 288 WP_202135321.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 997615..1057116 59501


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10861.77 Da        Isoelectric Point: 9.5726

>T153959 WP_000921935.1 NZ_CP051291:c1029944-1029663 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T153959 NZ_CP067255:c4791821-4791537 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12140.62 Da        Isoelectric Point: 5.2248

>AT153959 WP_000065286.1 NZ_CP051291:c1030251-1029937 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERRNA

Download         Length: 315 bp

>AT153959 NZ_CP067255:c4792053-4791811 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L0PNN7

Antitoxin

Source ID Structure
AlphaFold DB G2MA82

References