Detailed information of TA system TA153951

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 5175771..5176183
• Replicon: chromosome
• Accession: NZ_CP051263
• Organism: Escherichia coli CFT073

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: HGG68_RS24800
• Protein ID: WP_000132630.1
• Coordinates: 5175771..5176112 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	5176107..5176183 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGG68_RS24780	5170840..5172120	-	1281	WP_024182263.1	DUF445 domain-containing protein	-
HGG68_RS24785	5172305..5173225	+	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
HGG68_RS24790	5173453..5173533	+	81	WP_020233658.1	hypothetical protein	-
HGG68_RS24795	5173631..5175724	+	2094	WP_000648234.1	DUF262 domain-containing protein	-
HGG68_RS24800	5175771..5176112	-	342	WP_000132630.1	endoribonuclease SymE	Toxin
-	5176107..5176183	+	77	NuclAT_6	-	Antitoxin
-	5176107..5176183	+	77	NuclAT_6	-	Antitoxin
-	5176107..5176183	+	77	NuclAT_6	-	Antitoxin
-	5176107..5176183	+	77	NuclAT_6	-	Antitoxin
-	5176107..5176183	+	77	NuclAT_7	-	Antitoxin
-	5176107..5176183	+	77	NuclAT_7	-	Antitoxin
-	5176107..5176183	+	77	NuclAT_7	-	Antitoxin
-	5176107..5176183	+	77	NuclAT_7	-	Antitoxin
HGG68_RS24805	5176333..5178102	-	1770	WP_000110076.1	restriction endonuclease subunit S	-
HGG68_RS24810	5178102..5179571	-	1470	WP_001315223.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T153951 WP_000132630.1 NZ_CP051263:c5176112-5175771 [Escherichia coli CFT073]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T153951 NZ_CP067255:c720860-720483 [Klebsiella pneumoniae]
ATGAAAACATTACCCGACACACACGAACGGGAGGCGTCACGCTGCTCGTCTCCTGTGACAATCTGGCAGACACTCCTGGC
CCGGCTGCTGGGCCAGCATTACAGCCTCACGCTGAATGACACGCCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAGTACGCGCTGGTACGTACCGACCAGCCGGGATTC
GGCACCTGTGCCCATTCGCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGTTGACCCGCAG
CAACTACAGAACGGTGAACGACATTATCCGGGGTAAAGATGCGGAGGCAAAACAATGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT153951 NZ_CP051263:5176107-5176183 [Escherichia coli CFT073]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin