Detailed information of TA system TA153926

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 16186..16444
• Replicon: chromosome
• Accession: NZ_CP051263
• Organism: Escherichia coli CFT073

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HGG68_RS00080
• Protein ID: WP_001181672.1
• Coordinates: 16186..16395 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	16387..16444 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGG68_RS00060	11431..12144	-	714	WP_001102391.1	acidic protein MsyB	-
HGG68_RS00065	12170..12574	-	405	WP_000843687.1	DUF2541 family protein	-
HGG68_RS00070	12946..14862	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HGG68_RS00075	14951..16081	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HGG68_RS00080	16186..16395	-	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	16387..16444	+	58	-	-	Antitoxin
HGG68_RS00085	16953..17714	+	762	WP_001274832.1	hypothetical protein	-
HGG68_RS00090	17734..19227	+	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
HGG68_RS00095	19356..20615	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T153926 WP_001181672.1 NZ_CP051263:c16395-16186 [Escherichia coli CFT073]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T153926 NZ_CP067250:c301286-300909 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT153926 NZ_CP051263:16387-16444 [Escherichia coli CFT073]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin