Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 234263..234849 Replicon chromosome
Accession NZ_CP051261
Organism Xanthomonas sp. SI

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HEP75_RS01050 Protein ID WP_185821790.1
Coordinates 234263..234544 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HEP75_RS01055 Protein ID WP_185814804.1
Coordinates 234559..234849 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEP75_RS01035 230142..230837 - 696 WP_185816439.1 ribonuclease H-like domain-containing protein -
HEP75_RS01040 231254..231484 - 231 WP_185825122.1 hypothetical protein -
HEP75_RS01045 231597..234092 - 2496 WP_185825123.1 DEAD/DEAH box helicase -
HEP75_RS01050 234263..234544 + 282 WP_185821790.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEP75_RS01055 234559..234849 + 291 WP_185814804.1 HigA family addiction module antidote protein Antitoxin
HEP75_RS01060 234998..235660 + 663 WP_185821791.1 hemolysin III family protein -
HEP75_RS01065 235788..236240 + 453 WP_185825124.1 hypothetical protein -
HEP75_RS01070 236426..236845 - 420 WP_185825125.1 BA14K family protein -
HEP75_RS01075 237066..237359 - 294 WP_185821794.1 DUF2388 domain-containing protein -
HEP75_RS01080 237386..237859 + 474 WP_185825126.1 hypothetical protein -
HEP75_RS01085 238242..239153 - 912 WP_185825127.1 hypothetical protein -
HEP75_RS01090 239371..239598 - 228 WP_185816440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10757.32 Da        Isoelectric Point: 9.8979

>T153922 WP_185821790.1 NZ_CP051261:234263-234544 [Xanthomonas sp. SI]
VIRNFVDKEAEKIWQGTPSRRLPADIQAVARRKLRMLNSAATLDDLRVPPANRLEALKGNRKGQCSIRINDQWRVCFQWK
DGDALDVEIVDYH

Download         Length: 282 bp

>T153922 NZ_CP067245:4089885-4090220 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10401.03 Da        Isoelectric Point: 10.5812

>AT153922 WP_185814804.1 NZ_CP051261:234559-234849 [Xanthomonas sp. SI]
MKTLPNIHPGEVLLEEFLTPLGISQNALARAAGVPPRRINEIVLGKRSVSADSAIRLAAALGTSERFWLGLQADYDLEQA
RRALGAQARKIERIAA

Download         Length: 291 bp

>AT153922 NZ_CP067245:4089637-4089885 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References