Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 41139..41624 Replicon chromosome
Accession NZ_CP051227
Organism Lacticaseibacillus rhamnosus strain LDTM7511

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag HF522_RS14095 Protein ID WP_230318488.1
Coordinates 41517..41624 (+) Length 36 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A807RQZ2
Locus tag HF522_RS00195 Protein ID WP_005684270.1
Coordinates 41139..41411 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF522_RS00170 (HF522_00200) 37409..38290 + 882 WP_005684263.1 class II fructose-1,6-bisphosphate aldolase -
HF522_RS00175 (HF522_00205) 38419..38637 - 219 WP_014569141.1 hypothetical protein -
HF522_RS00180 (HF522_00210) 38759..39334 - 576 WP_014569140.1 DNA-3-methyladenine glycosylase I -
HF522_RS00185 (HF522_00215) 39488..40651 - 1164 WP_005684266.1 MFS transporter -
HF522_RS00190 (HF522_00220) 40733..41026 - 294 WP_005684269.1 metalloregulator ArsR/SmtB family transcription factor -
HF522_RS00195 (HF522_00225) 41139..41411 + 273 WP_005684270.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HF522_RS14095 41517..41624 + 108 WP_230318488.1 type II toxin-antitoxin system YafQ family toxin Toxin
HF522_RS00205 (HF522_00235) 41848..43257 + 1410 WP_005684271.1 3'-5' exonuclease -
HF522_RS00210 (HF522_00245) 44008..45423 + 1416 WP_015764852.1 IS5-like element ISLrh2 family transposase -
HF522_RS00215 (HF522_00250) 45471..46307 + 837 WP_014569137.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-30)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3997.68 Da        Isoelectric Point: 4.6219

>T153915 WP_230318488.1 NZ_CP051227:41517-41624 [Lacticaseibacillus rhamnosus]
MHVAPDWLLVYKVDAEALILMFLATGTHRDTLNIE

Download         Length: 108 bp

>T153915 NZ_CP067245:2590254-2590634 [Escherichia coli]
ATGCAAACCTTATCCGCCATCCCGAAGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGGAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGGAGCAACATTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10323.01 Da        Isoelectric Point: 10.7322

>AT153915 WP_005684270.1 NZ_CP051227:41139-41411 [Lacticaseibacillus rhamnosus]
MAKESRIRNWINTITRKRALHVLNRLGLERFSAINMYWKRIGDTGALPFTLEMSFADQLRFAEADVKAGRIKSFKTVGAL
MKDLYSDVDG

Download         Length: 273 bp

>AT153915 NZ_CP067245:2589831-2590196 [Escherichia coli]
TTGTCGAATCCAATACCTCCAGTAAACCATGATGTCTCTGAGCCCTGGTGGGGGCTGAAACCGGGCATCACTCCGTGTTT
TGGCGCACGACTGGTACAGGAAGGCAACCGCCTGCATTATCTGGCTGATCGGGCCAGTATCGCCGGTGTGTTCAGCGATG
CGGATTTACGCCATCTCGATCAAGCATTTCCGGTACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCTGCCATCAGCACTGTGTCACGTTATATGCAAAAGGGCTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATTTATCCGACACCAGACGACAGCATAACCCGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A807RQZ2

References