Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 610111..610910 Replicon chromosome
Accession NZ_CP051219
Organism Escherichia coli strain SFE8

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HF527_RS02970 Protein ID WP_000347253.1
Coordinates 610111..610575 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag HF527_RS02975 Protein ID WP_024251361.1
Coordinates 610575..610910 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF527_RS02940 605112..605546 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
HF527_RS02945 605564..606442 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
HF527_RS02950 606432..607211 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
HF527_RS02955 607222..607695 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
HF527_RS02960 607718..608998 - 1281 WP_000681910.1 tagatose-bisphosphate aldolase subunit KbaZ -
HF527_RS02965 609247..610056 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
HF527_RS02970 610111..610575 - 465 WP_000347253.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
HF527_RS02975 610575..610910 - 336 WP_024251361.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
HF527_RS02980 611059..612630 - 1572 WP_001273766.1 galactarate dehydratase -
HF527_RS02985 613005..614339 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
HF527_RS02990 614355..615125 + 771 WP_001058226.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17764.14 Da        Isoelectric Point: 9.4947

>T153848 WP_000347253.1 NZ_CP051219:c610575-610111 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEETH

Download         Length: 465 bp

>T153848 NZ_CP067232:c4054600-4054424 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12348.90 Da        Isoelectric Point: 4.8616

>AT153848 WP_024251361.1 NZ_CP051219:c610910-610575 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
SQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT153848 NZ_CP067232:c4054378-4053962 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References