Detailed information of TA system TA153821

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4727067..4727669
• Replicon: chromosome
• Accession: NZ_CP051213
• Organism: Salmonella enterica strain SCSW714

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A603E470
• Locus tag: HGB43_RS22800
• Protein ID: WP_023138876.1
• Coordinates: 4727358..4727669 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HGB43_RS22795
• Protein ID: WP_000362050.1
• Coordinates: 4727067..4727357 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGB43_RS22780 (4724560)	4724560..4725462	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
HGB43_RS22785 (4725459)	4725459..4726094	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
HGB43_RS22790 (4726091)	4726091..4727020	+	930	WP_023138877.1	formate dehydrogenase accessory protein FdhE	-
HGB43_RS22795 (4727067)	4727067..4727357	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
HGB43_RS22800 (4727358)	4727358..4727669	-	312	WP_023138876.1	hypothetical protein	Toxin
HGB43_RS22805 (4727887)	4727887..4728801	+	915	WP_023138875.1	alpha/beta hydrolase	-
HGB43_RS22810 (4728827)	4728827..4729768	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
HGB43_RS22815 (4729813)	4729813..4730250	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
HGB43_RS22820 (4730247)	4730247..4731119	-	873	WP_000921423.1	virulence factor BrkB family protein	-
HGB43_RS22825 (4731113)	4731113..4731712	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12356.30 Da
• Isoelectric Point: 9.4460

>T153821 WP_023138876.1 NZ_CP051213:c4727669-4727358 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T153821 NZ_CP067141:c216796-216479 [Paracoccus saliphilus]
TTGGACGCGTTGAAGCGTCTCGGTATTGCCGAGCCTGCTGCCCGCGATCTTGCGCATATCGTGGATTACATCGCATTGGA
CAATCCCGCTTCCGCGGAGAACGTGTATCGGGAAATCGTCCAGGCAGCGGAGCGATTGCCCGAGTTCCCAGCCTTGGGGC
GTCCGGGGCGCCATCCTGAGACGAGGGAACTGAGCATTACGGGGCTGCCCTATCTGATCGTCTACGAAGTTGGTGTTGAT
ACGGTGACGATATTGGCGGTGTTTCATACCTCCCGAGACCTCTCTCAAGCACCGCATGACAGGATGCAGGGCAGCTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT153821 WP_000362050.1 NZ_CP051213:c4727357-4727067 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT153821 NZ_CP067141:c217035-216784 [Paracoccus saliphilus]
ATGGCGCAGCGCACCGCATCCGAACCGATCACGATCCGCACCGCCAAGGTGGCCGAAATCGATGCCTTGGCGAATGCCAT
GGACCGTTCTCGCAACTATATCGTCAATCAAGCGATCGAGCGATATCTGGAGGCGAACGCCTGGCAGATGGAACGGATCG
AGGAGGGGATTGCGGCTTCCCGTGAGGGTAAGGTTGTTCCTGCCGATGAGGTGTTTGCCGGAATTGCCGCCAGGCATGGT
TGGACGCGTTGA

Structures

Toxin

• AlphaFold DB: A0A603E470