Detailed information of TA system TA153814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2137571..2138298
• Replicon: chromosome
• Accession: NZ_CP051213
• Organism: Salmonella enterica strain SCSW714

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8E5IJ81
• Locus tag: HGB43_RS10425
• Protein ID: WP_000558157.1
• Coordinates: 2137987..2138298 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HGB43_RS10420
• Protein ID: WP_000561389.1
• Coordinates: 2137571..2137990 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGB43_RS10395 (2134379)	2134379..2134920	+	542	Protein_2043	transposase	-
HGB43_RS10400 (2135066)	2135066..2135206	-	141	WP_001576018.1	hypothetical protein	-
HGB43_RS10405 (2135372)	2135372..2135641	-	270	WP_077908593.1	hypothetical protein	-
HGB43_RS10410 (2136011)	2136011..2136430	+	420	WP_023137951.1	GNAT family N-acetyltransferase	-
HGB43_RS10415 (2136666)	2136666..2137318	-	653	Protein_2047	glycosyltransferase	-
HGB43_RS10420 (2137571)	2137571..2137990	-	420	WP_000561389.1	helix-turn-helix domain-containing protein	Antitoxin
HGB43_RS10425 (2137987)	2137987..2138298	-	312	WP_000558157.1	type II toxin-antitoxin system HigB family toxin	Toxin
HGB43_RS10430 (2138477)	2138477..2138776	+	300	WP_000775225.1	hypothetical protein	-
HGB43_RS10435 (2138806)	2138806..2139015	+	210	WP_023137948.1	hypothetical protein	-
HGB43_RS10440 (2139119)	2139119..2139676	+	558	WP_000179886.1	hypothetical protein	-
HGB43_RS10450 (2141180)	2141180..2141638	+	459	WP_001195655.1	hypothetical protein	-
HGB43_RS10455 (2141750)	2141750..2141902	-	153	WP_157794946.1	hypothetical protein	-
HGB43_RS10460 (2142054)	2142054..2142530	-	477	WP_023138823.1	hypothetical protein	-
HGB43_RS10465 (2142859)	2142859..2143254	-	396	WP_000422887.1	DUF1398 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	sopE2	2136011..2145109	9098
	-	inside	IScluster/Tn	-	-	2134582..2140854	6272

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (22-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (85-138)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12425.26 Da
• Isoelectric Point: 10.1376

>T153814 WP_000558157.1 NZ_CP051213:c2138298-2137987 [Salmonella enterica]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRKVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE

Nucleotide

• Length: 312 bp

>T153814 NZ_CP067113:60512-60805 [Luteimonas sp. MC1750]
ATGACCAAAGTAAAAGAGAAGTTCAGCCGCTACGACACCGCAGATTACCTGGAGACGGAAGCGGACATTGCTGCGTACTT
GAACGCATGCGCAGAAGAAGATGATCCCGCGCTGCTGGTGGCTGCGCTCGGAGATGTGGCCCGAGCTCGCAACATGACCC
AGCTCGCCGAGAAAACCGGCATGACCCGAATGGGCTTGTACAAGGCTCTTTCGGGGCAAGGCAACCCGAGCTTCGCTACC
GTATCCAAGGTCGCGCATGCGCTTGGCCTAAAGATCACGGTGGCAGCGACCTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15301.49 Da
• Isoelectric Point: 4.6286

>AT153814 WP_000561389.1 NZ_CP051213:c2137990-2137571 [Salmonella enterica]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL

Nucleotide

• Length: 420 bp

>AT153814 NZ_CP067113:60213-60509 [Luteimonas sp. MC1750]
ATGGTCGAGATCCTCAAGAGCGACACTTTCGATGCATGGTTACGCGCTTTGCGCGACCGTCAAGTAAAGGCTCGCATAGA
GGTGCGTATCCGGCGGTTGTCGCTGGAGAACCCAGGGCAGCACCGAGCGCTCAAGGGTGGGATCTGCGAGCTCAAAATAG
ATCACGGCCCCGGGTATCGGGTTTACTACACCTTTCGTAATCAAACACTTGTGCTGCTGCTCTGCGGCGGCACCAAATCC
ACCCAAAGCCAAGACATCAAGCTTGCGCAGAGCATTGCCAAGCAATGGGAGGACTAG