Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 723221..723850 Replicon chromosome
Accession NZ_CP051203
Organism Treponema sp. OMZ 792

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4O03_RS03400 Protein ID WP_253678581.1
Coordinates 723542..723850 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4O03_RS03395 Protein ID WP_253687396.1
Coordinates 723221..723532 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O03_RS03360 (E4O03_03340) 718327..718665 + 339 WP_253687387.1 hypothetical protein -
E4O03_RS03365 (E4O03_03345) 718703..719146 - 444 WP_253678575.1 SUF system NifU family Fe-S cluster assembly protein -
E4O03_RS03370 (E4O03_03350) 719173..720375 - 1203 WP_253687388.1 SufS family cysteine desulfurase -
E4O03_RS03375 (E4O03_03355) 720597..720884 + 288 WP_253687389.1 putative addiction module antidote protein -
E4O03_RS03380 (E4O03_03360) 721012..721275 + 264 WP_253687390.1 hypothetical protein -
E4O03_RS03385 (E4O03_03365) 721244..721600 + 357 WP_253687392.1 helix-turn-helix transcriptional regulator -
E4O03_RS03390 (E4O03_03370) 721913..723094 + 1182 WP_253687394.1 formylglycine-generating enzyme family protein -
E4O03_RS03395 (E4O03_03375) 723221..723532 - 312 WP_253687396.1 NadS family protein Antitoxin
E4O03_RS03400 (E4O03_03380) 723542..723850 - 309 WP_253678581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4O03_RS03410 (E4O03_03390) 724193..725785 - 1593 WP_253687398.1 peptide ABC transporter substrate-binding protein -
E4O03_RS03415 (E4O03_03395) 725859..727262 - 1404 WP_253687400.1 hypothetical protein -
E4O03_RS03420 (E4O03_03400) 727372..727665 + 294 WP_253687401.1 CRISPR-associated protein Cas2 -
E4O03_RS03425 (E4O03_03405) 727670..728792 + 1123 WP_253687403.1 peptide chain release factor 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11735.97 Da        Isoelectric Point: 10.5337

>T153787 WP_253678581.1 NZ_CP051203:c723850-723542 [Treponema sp. OMZ 792]
MKIIETPVFTKQINKLLDEDTYKQFKEYLVCNPLKGKLIKGGAGIRKIRWGKKNTGKSGGVRIIYFIKTETKIYLLFAYS
KSDAENITKKQINMLASFIKDL

Download         Length: 309 bp

>T153787 NZ_CP067093:3022391-3022494 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11648.56 Da        Isoelectric Point: 9.6545

>AT153787 WP_253687396.1 NZ_CP051203:c723532-723221 [Treponema sp. OMZ 792]
MFKRKKMSDEMFTELLQSVKEAVLIEKGEIPPSRVFEIEPLDIAKIRDKTNKTQEEFAAMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLKGG

Download         Length: 312 bp

>AT153787 NZ_CP067093:c3022501-3022333 [Klebsiella michiganensis]
AATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGTGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References