Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 722911..723540 Replicon chromosome
Accession NZ_CP051199
Organism Treponema sp. OMZ 788

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4O00_RS03385 Protein ID WP_253678581.1
Coordinates 723232..723540 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4O00_RS03380 Protein ID WP_253678580.1
Coordinates 722911..723222 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O00_RS03350 (E4O00_03205) 718585..718923 + 339 WP_253678574.1 hypothetical protein -
E4O00_RS03355 (E4O00_03210) 718961..719404 - 444 WP_253678575.1 SUF system NifU family Fe-S cluster assembly protein -
E4O00_RS03360 (E4O00_03215) 719431..720633 - 1203 WP_253678576.1 SufS family cysteine desulfurase -
E4O00_RS03365 (E4O00_03220) 720759..721874 + 1116 WP_253678577.1 ISAs1 family transposase -
E4O00_RS03370 (E4O00_03225) 722020..722274 + 255 WP_253678578.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4O00_RS03375 (E4O00_03230) 722258..722608 + 351 WP_253678579.1 helix-turn-helix transcriptional regulator -
E4O00_RS03380 (E4O00_03235) 722911..723222 - 312 WP_253678580.1 NadS family protein Antitoxin
E4O00_RS03385 (E4O00_03240) 723232..723540 - 309 WP_253678581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4O00_RS03390 724087..725046 - 960 WP_253678582.1 BRO family protein -
E4O00_RS03395 (E4O00_03255) 725149..725835 - 687 WP_253678583.1 antA/AntB antirepressor family protein -
E4O00_RS03400 (E4O00_03260) 725975..726913 - 939 WP_253678584.1 BRO family protein -
E4O00_RS03405 (E4O00_03265) 726903..727256 - 354 WP_253678585.1 helix-turn-helix transcriptional regulator -
E4O00_RS03410 (E4O00_03270) 727380..727562 + 183 WP_253678586.1 hypothetical protein -
E4O00_RS03415 (E4O00_03275) 727685..727903 + 219 WP_253678587.1 hypothetical protein -
E4O00_RS03420 (E4O00_03280) 727900..728259 + 360 WP_253678588.1 hypothetical protein -
E4O00_RS03425 (E4O00_03285) 728256..728498 + 243 WP_253678589.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 722258..780903 58645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11735.97 Da        Isoelectric Point: 10.5337

>T153777 WP_253678581.1 NZ_CP051199:c723540-723232 [Treponema sp. OMZ 788]
MKIIETPVFTKQINKLLDEDTYKQFKEYLVCNPLKGKLIKGGAGIRKIRWGKKNTGKSGGVRIIYFIKTETKIYLLFAYS
KSDAENITKKQINMLASFIKDL

Download         Length: 309 bp

>T153777 NZ_CP067091:c3776273-3775788 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11664.56 Da        Isoelectric Point: 8.5454

>AT153777 WP_253678580.1 NZ_CP051199:c723222-722911 [Treponema sp. OMZ 788]
MFKRKKMSDEMFTELLQSVKEAVLIEKGEIIPSRVFEIEPLDIAKIRDKTNKTQEEFAAMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQGG

Download         Length: 312 bp

>AT153777 NZ_CP067091:c3776548-3776261 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References