Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2571539..2572049 Replicon chromosome
Accession NZ_CP051197
Organism Treponema vincentii strain OMZ 802

Toxin (Protein)


Gene name yoeB Uniprot ID S3LB99
Locus tag E4N70_RS11590 Protein ID WP_016518798.1
Coordinates 2571789..2572049 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S3LAR5
Locus tag E4N70_RS11585 Protein ID WP_016518797.1
Coordinates 2571539..2571796 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N70_RS11560 (E4N70_11500) 2567401..2567886 - 486 WP_006187617.1 pantetheine-phosphate adenylyltransferase -
E4N70_RS11565 (E4N70_11505) 2568502..2569080 - 579 WP_253818330.1 hypothetical protein -
E4N70_RS11570 (E4N70_11510) 2569049..2569519 - 471 WP_253818331.1 hypothetical protein -
E4N70_RS11575 (E4N70_11515) 2569613..2570350 - 738 WP_253812682.1 hypothetical protein -
E4N70_RS11580 (E4N70_11520) 2570795..2571346 - 552 WP_253818332.1 hypothetical protein -
E4N70_RS11585 (E4N70_11525) 2571539..2571796 + 258 WP_016518797.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E4N70_RS11590 (E4N70_11530) 2571789..2572049 + 261 WP_016518798.1 Txe/YoeB family addiction module toxin Toxin
E4N70_RS11595 (E4N70_11535) 2572180..2575698 - 3519 WP_253818333.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10606.11 Da        Isoelectric Point: 9.7986

>T153772 WP_016518798.1 NZ_CP051197:2571789-2572049 [Treponema vincentii]
MNKLFTDEAWDDYTFWFNTDKKILKKINDLIKEIERTPFTGKGKPEPLKYSLSGYWSRRINHEHRIVYQVDNDQLVFISF
RYHYKK

Download         Length: 261 bp

>T153772 NZ_CP067091:2984959-2985486 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10191.52 Da        Isoelectric Point: 6.3284

>AT153772 WP_016518797.1 NZ_CP051197:2571539-2571796 [Treponema vincentii]
MDVITYSDLRRNLKTYMDKVYYDYEPLLIARKNSENLVLLSVHEYNSLIETDYLLRDEANAKHLKKSVEQHKNGHLQKHE
LLENE

Download         Length: 258 bp

>AT153772 NZ_CP067091:2984672-2984962 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3LB99

Antitoxin

Source ID Structure
AlphaFold DB S3LAR5

References