Detailed information of TA system TA153768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-Phd
• Location: 388682..389184
• Replicon: chromosome
• Accession: NZ_CP051197
• Organism: Treponema vincentii strain OMZ 802

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: S3L9E4
• Locus tag: E4N70_RS01950
• Protein ID: WP_016519148.1
• Coordinates: 388682..388942 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: S3LA43
• Locus tag: E4N70_RS01955
• Protein ID: WP_016519149.1
• Coordinates: 388942..389184 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N70_RS01940 (E4N70_01925)	384866..387001	+	2136	WP_253818626.1	single-stranded-DNA-specific exonuclease RecJ	-
E4N70_RS01945 (E4N70_01930)	387229..388452	-	1224	WP_253818627.1	M20 family metallopeptidase	-
E4N70_RS01950 (E4N70_01935)	388682..388942	-	261	WP_016519148.1	Txe/YoeB family addiction module toxin	Toxin
E4N70_RS01955 (E4N70_01940)	388942..389184	-	243	WP_016519149.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E4N70_RS01960 (E4N70_01945)	389318..390823	+	1506	WP_253818628.1	hemolysin family protein	-
E4N70_RS01965 (E4N70_01950)	390820..392082	+	1263	WP_253818629.1	hemolysin family protein	-
E4N70_RS01970 (E4N70_01955)	392237..393451	+	1215	WP_253818630.1	galactokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10367.07 Da
• Isoelectric Point: 9.9941

>T153768 WP_016519148.1 NZ_CP051197:c388942-388682 [Treponema vincentii]
MWTVVYSKQAAKDSKKIELSNLKQTVKYLIEVIKNNPFENSPPYEKLVGDLAGKYSRRINIQHRLIYEVFEKEHIVRILR
MWTHYE

Nucleotide

• Length: 261 bp

>T153768 NZ_CP067091:c339504-339229 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9149.41 Da
• Isoelectric Point: 4.1191

>AT153768 WP_016519149.1 NZ_CP051197:c389184-388942 [Treponema vincentii]
MTILTATAARINLYNLIDQTKEFHEPIIISGKRNNAVLISEDDWDAIQETLYLCSIPGMRESIIEASKEPLEESIKELDW

Nucleotide

• Length: 243 bp

>AT153768 NZ_CP067091:339239-339661 [Salmonella enterica subsp. enterica serovar Typhimurium]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: S3L9E4

Antitoxin

• AlphaFold DB: S3LA43