Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1787136..1787755 Replicon chromosome
Accession NZ_CP051196
Organism Treponema sp. OMZ 906

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E4N69_RS07985 Protein ID WP_162664818.1
Coordinates 1787441..1787755 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E4N69_RS07980 Protein ID WP_253713997.1
Coordinates 1787136..1787444 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N69_RS07960 (E4N69_07955) 1782468..1782980 - 513 WP_253713993.1 TIGR03546 family protein -
E4N69_RS07965 (E4N69_07965) 1783579..1784265 + 687 WP_162663796.1 outer membrane lipoprotein carrier protein LolA -
E4N69_RS07970 (E4N69_07970) 1784348..1785466 + 1119 WP_253823494.1 helix-turn-helix domain-containing protein -
E4N69_RS07975 (E4N69_07975) 1785459..1787042 + 1584 WP_253823495.1 MiaB/RimO family radical SAM methylthiotransferase -
E4N69_RS07980 (E4N69_07980) 1787136..1787444 - 309 WP_253713997.1 NadS family protein Antitoxin
E4N69_RS07985 (E4N69_07985) 1787441..1787755 - 315 WP_162664818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N69_RS07995 (E4N69_07995) 1788454..1790106 + 1653 WP_253823496.1 nucleoside kinase -
E4N69_RS08000 (E4N69_08000) 1790418..1790996 - 579 WP_253823497.1 hypothetical protein -
E4N69_RS08005 (E4N69_08005) 1791342..1791902 + 561 WP_253823498.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11961.14 Da        Isoelectric Point: 10.3625

>T153764 WP_162664818.1 NZ_CP051196:c1787755-1787441 [Treponema sp. OMZ 906]
MELIETPVFKKQIDRLLDDLTYTQFKEYLVCNPLKGKLIRGGGGIRKIRWGKKNTGKSGGVRIIYFIKTDTQIYLLFAYA
KNESDNLTKKQTNMLAAFVKEVLL

Download         Length: 315 bp

>T153764 NZ_CP067089:256736-257131 [Breznakiella homolactica]
ATGTACCTCCTGGATACCAATATCTGCCTATACCTTATCAAGGAGCGTCCCGAAGCGGTCTTAAAAAACCTCAGGAAAAA
GCGTTCCAAGGGGATAGCCATTTCCTCAATCACCCTGGCGGAACTGGAATACGGTGTAGAAAACAGCAAGTTTCCGGAGA
AGAACAAAATCGCCCTGATTAAGTTTCTTTCTATAATAACCATCCTGCCCTTTGAAGCCAAAGCGGCGGAGGCCTATGGA
AAGATTAAGGCCGATTTAAAACGGAGGGGCCGTATCATCGGACCGCTGGATATACTCATAGCCGCCCACGCCAAATCGGA
AGATTTGGTCCTGGTAACTAATAATACCAGGGAATTTGAGCGGATAGCGGATGTAAAGATAGAAAACTGGATGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11438.26 Da        Isoelectric Point: 7.2050

>AT153764 WP_253713997.1 NZ_CP051196:c1787444-1787136 [Treponema sp. OMZ 906]
MIGHKKMSDEMFSELIQSIKEAALIEKGEMEPARVSVIDALDIAAIRNKTHKTQEEFATMLNISIGTLRNWEQGRRKPDG
AALSLLKVVSADPQYVEKVLRT

Download         Length: 309 bp

>AT153764 NZ_CP067089:256506-256736 [Breznakiella homolactica]
ATGCAAACAGCGAAACTATTTACCAATGGGCGGAGCCAGGCCGTACGGCTGCCCAAGGATTACCAGTTTATCGGAGAAGA
TGTCTACATCCAAAAAGTAGGGGACGCGGTCATCCTCTTTCCCAAGGACAAGGACTGGGAAATCTTTCTCGACGGGTTAA
ACAGCTTCTCCGACGACTTTCTGGCAGACGGCTGCGACCAGGGGATTAAGGGCGAACGGGAAGCCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References