Detailed information of TA system TA153763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe(toxin)
• Location: 1002433..1002920
• Replicon: chromosome
• Accession: NZ_CP051196
• Organism: Treponema sp. OMZ 906

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E4N69_RS04495
• Protein ID: WP_253824882.1
• Coordinates: 1002675..1002920 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: E4N69_RS04490
• Protein ID: WP_230978026.1
• Coordinates: 1002433..1002564 (+)
• Length: 44 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N69_RS04445 (E4N69_04420)	997787..998296	+	510	WP_253824641.1	hypothetical protein	-
E4N69_RS04450 (E4N69_04425)	998289..998510	+	222	WP_253824642.1	hypothetical protein	-
E4N69_RS04455 (E4N69_04430)	998686..998964	+	279	Protein_867	tyrosine-type recombinase/integrase	-
E4N69_RS04460 (E4N69_04435)	999094..999387	+	294	WP_253824643.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E4N69_RS04465 (E4N69_04440)	999719..1000000	+	282	WP_162662961.1	helix-turn-helix transcriptional regulator	-
E4N69_RS04470 (E4N69_04445)	1000200..1000424	+	225	WP_162662963.1	hypothetical protein	-
E4N69_RS04475 (E4N69_04450)	1000417..1000839	+	423	WP_230978025.1	PIN domain-containing protein	-
E4N69_RS04480 (E4N69_04455)	1001159..1002046	+	888	WP_253824644.1	carbon-nitrogen hydrolase family protein	-
E4N69_RS04485 (E4N69_04460)	1002153..1002371	+	219	WP_162662968.1	sterile alpha motif-like domain-containing protein	-
E4N69_RS04490	1002433..1002564	+	132	WP_230978026.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E4N69_RS04495 (E4N69_04470)	1002675..1002920	+	246	WP_253824882.1	Txe/YoeB family addiction module toxin	Toxin
E4N69_RS04500	1002954..1003064	+	111	Protein_876	tyrosine-type recombinase/integrase	-
E4N69_RS04505 (E4N69_04480)	1003272..1004084	+	813	WP_253824645.1	hypothetical protein	-
E4N69_RS04510 (E4N69_04485)	1004529..1005404	+	876	WP_253824646.1	hypothetical protein	-
E4N69_RS04515 (E4N69_04490)	1005728..1006033	+	306	WP_253824647.1	zinc ribbon domain-containing protein	-
E4N69_RS04520 (E4N69_04495)	1006038..1006397	+	360	WP_253715337.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-73)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-43)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9625.31 Da
• Isoelectric Point: 10.3178

>T153763 WP_253824882.1 NZ_CP051196:1002675-1002920 [Treponema sp. OMZ 906]
MWTVVYLKQAAKDSKKIELSNLKPTVKHLIEVIKNNSFENPSPYEKLVGDLTGKYSRRINIQHRLVYEVFEKEHIVRILR
M

Nucleotide

• Length: 246 bp

>T153763 NZ_CP067088:c1611852-1611589 [Limosilactobacillus fermentum]
ATGAGTTACGCGATCAAACTCAAGCGGAGCGCTAATAGAGATCTCAAGAAAATTAAGGGGTCATATTTAGAAAAGAGCTT
CTTGCAAATAATTGAGCAGCTCCGTAAAGACCCCTTGGCACCCAACCAAGGCTTTGAAAAATTAGTACCGCCAATTAAGG
GCTTTTACTCCCGGCGGATTAACATTCAGCACCGACTCGTCTATAAGGTTGATCAAGACACGCAAACTGTGATCATCTAT
TCTGCGTGGTCACATTACGAATAG

Antitoxin

Protein

• Length: 44 a.a.
• Molecular weight: 4777.38 Da
• Isoelectric Point: 4.7025

>AT153763 WP_230978026.1 NZ_CP051196:1002433-1002564 [Treponema sp. OMZ 906]
MTAMTATAARTNLYNLIDQTRDCHEPIIISGKRNNAVLISEDD

Nucleotide

• Length: 132 bp

>AT153763 NZ_CP067088:c1612103-1611849 [Limosilactobacillus fermentum]
ATGGACCAAATTGTAACCCCAACGCAAGCACGGAAAGATTTATTCAAAATAATCAAAAGGATCAATGAAAATAATGAGCC
GGTTGTGATTAAGCCGACCAGGGCGGATGAAAAGAGCGTTGTCGTCATTGGTGAAGATGACTGGAAAGCAATCCAAGAAA
CGTTATTTTTGGTTAATCACGGTGTTGACAAGCAAATTAAAGAACGGGAAAACGAGCCGCTCGACGACTTTGATGATGTT
TGGGGTCAACTATGA