Detailed information of TA system TA153758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe(toxin)
• Location: 923592..924094
• Replicon: chromosome
• Accession: NZ_CP051195
• Organism: Treponema sp. OMZ 803 strain BF2M

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ABH09_RS04280
• Protein ID: WP_253715333.1
• Coordinates: 923834..924094 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: ABH09_RS04275
• Protein ID: WP_253715332.1
• Coordinates: 923592..923723 (+)
• Length: 44 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABH09_RS04240 (ABH09_04235)	919774..920418	+	645	WP_253715328.1	hypothetical protein	-
ABH09_RS04245 (ABH09_04240)	920527..920883	+	357	WP_253715329.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ABH09_RS04250 (ABH09_04245)	920880..921161	+	282	WP_016519370.1	helix-turn-helix transcriptional regulator	-
ABH09_RS04255 (ABH09_04250)	921359..921583	+	225	WP_016519371.1	hypothetical protein	-
ABH09_RS04260 (ABH09_04255)	921576..921998	+	423	WP_253715330.1	PIN domain-containing protein	-
ABH09_RS04265 (ABH09_04260)	922318..923205	+	888	WP_253715331.1	carbon-nitrogen hydrolase family protein	-
ABH09_RS04270 (ABH09_04265)	923312..923530	+	219	WP_162662968.1	sterile alpha motif-like domain-containing protein	-
ABH09_RS04275	923592..923723	+	132	WP_253715332.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ABH09_RS04280 (ABH09_04275)	923834..924094	+	261	WP_253715333.1	Txe/YoeB family addiction module toxin	Toxin
ABH09_RS04285 (ABH09_04280)	924479..924712	+	234	Protein_833	tyrosine-type recombinase/integrase	-
ABH09_RS04290 (ABH09_04285)	924875..925687	+	813	WP_253715334.1	hypothetical protein	-
ABH09_RS04295 (ABH09_04290)	926135..927010	+	876	WP_253715335.1	hypothetical protein	-
ABH09_RS04300 (ABH09_04295)	927347..927652	+	306	WP_253715336.1	zinc ribbon domain-containing protein	-
ABH09_RS04305 (ABH09_04300)	927657..928016	+	360	WP_253715337.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	910516..925687	15171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-43)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10333.09 Da
• Isoelectric Point: 10.1975

>T153758 WP_253715333.1 NZ_CP051195:923834-924094 [Treponema sp. OMZ 803]
MWTVVYLKQAAKDSKKIELSNLKPTVKHLIEVIKNNSFENPSPYEKLVGDLTGKYSRRINIQHRLVYEVFEKELIDRILR
MWTHYK

Nucleotide

• Length: 261 bp

>T153758 NZ_CP067072:c808061-807639 [Rhizobium sp. AB2/73]
ATGATTGTTCTCGACACCAACGTCATTTCCGAGCTGTGGAAGATCACGCCCGATCCGAATGTGTTGTCATGGATCGATGC
GCAGATGATCGAAACACTCTACCTCTCGATCATCACCGTTGCCGAATTGCGCTTCGGCTTGGCTGCGATGCCGGAGGGCA
AGCGGCGTACGATCTATCAAGGCCGATTGGAAAGAGAGGTTTTACCAGCTTTTGCCAACCGGGTTCTGCCTTTTGACTTG
GATGCCTCGCAAGCCTATGCCGATTTGATGGCGTTAGCGAGGAGGGCAGGCAAGTCCATTGGCACGGCAGATGGCTATAT
TGCCGCCACGGCTGCCTCACATGGCTTTATGGTAGCTACGCGCGATACTAGCCCTTTTGAAGCTGGCGGTTTAAGCGTCA
TCAACCCTTGGAACATGAAATGA

Antitoxin

Protein

• Length: 44 a.a.
• Molecular weight: 4793.42 Da
• Isoelectric Point: 4.7025

>AT153758 WP_253715332.1 NZ_CP051195:923592-923723 [Treponema sp. OMZ 803]
MTAMTATAARTNLYNLIDQTRDCHELIIISGKRNNAVLISEDD

Nucleotide

• Length: 132 bp

>AT153758 NZ_CP067072:c808315-808058 [Rhizobium sp. AB2/73]
ATGGCATCGATCACCATTCGCAATGTGTCGGACGAGGTGCACCGTGCGATCCGGGTGCGAGCTGCTATGCACGGTCGCAG
CACTGAAGCCGAGATCCGCGATATTCTGGAAAAGGCAGCAAAACCAGAAGGCCGCCTGAAGCTGGGTTCGCTGTTGACAT
CCATCGCTCGTGAAGCGGGGGGGCTAACCGAAGCCGAAGCTGAGGGTTTCAACCAGCTTCGCGATAAGACCCCGGTCGGG
CCGATTAGCTTCGAATGA