Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2465471..2465988 Replicon chromosome
Accession NZ_CP051191
Organism Staphylococcus aureus strain NGA102

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag HF084_RS12190 Protein ID WP_000113262.1
Coordinates 2465722..2465988 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag HF084_RS12185 Protein ID WP_000584499.1
Coordinates 2465471..2465722 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF084_RS12155 (2461169) 2461169..2461888 + 720 WP_000479576.1 amino acid ABC transporter permease -
HF084_RS12160 (2461885) 2461885..2462616 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
HF084_RS12165 (2462713) 2462713..2463963 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
HF084_RS12170 (2464218) 2464218..2464580 + 363 WP_000819840.1 DUF4467 domain-containing protein -
HF084_RS12175 (2464599) 2464599..2465198 + 600 WP_000162810.1 DsbA family protein -
HF084_RS12180 (2465226) 2465226..2465306 + 81 WP_223197974.1 hypothetical protein -
HF084_RS12185 (2465471) 2465471..2465722 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HF084_RS12190 (2465722) 2465722..2465988 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
HF084_RS12195 (2466023) 2466023..2466094 + 72 Protein_2374 hypothetical protein -
HF084_RS12200 (2466283) 2466283..2467836 + 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HF084_RS12205 (2468022) 2468022..2468489 + 468 WP_000153344.1 SRPBCC domain-containing protein -
HF084_RS12210 (2468573) 2468573..2468758 + 186 WP_000230293.1 hypothetical protein -
HF084_RS12215 (2468974) 2468974..2469798 + 825 WP_000594629.1 formate/nitrite transporter family protein -
HF084_RS12220 (2470032) 2470032..2470568 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T153745 WP_000113262.1 NZ_CP051191:2465722-2465988 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T153745 NZ_CP067069:250838-251188 [Bacillus sp. HNR-4]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT153745 WP_000584499.1 NZ_CP051191:2465471-2465722 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT153745 NZ_CP067069:250546-250833 [Bacillus sp. HNR-4]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References