Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2408599..2409122 Replicon chromosome
Accession NZ_CP051191
Organism Staphylococcus aureus strain NGA102

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag HF084_RS11915 Protein ID WP_000074045.1
Coordinates 2408856..2409122 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag HF084_RS11910 Protein ID WP_000587619.1
Coordinates 2408599..2408856 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF084_RS11890 (2403677) 2403677..2404870 + 1194 WP_103148479.1 MFS transporter -
HF084_RS11895 (2405094) 2405094..2405843 - 750 WP_000072465.1 CPBP family lipoprotein N-acylation protein LnsB -
HF084_RS11900 (2406039) 2406039..2407616 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
HF084_RS11905 (2407784) 2407784..2408239 - 456 WP_000732079.1 DUF1307 domain-containing protein -
HF084_RS11910 (2408599) 2408599..2408856 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HF084_RS11915 (2408856) 2408856..2409122 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
HF084_RS11920 (2409477) 2409477..2410553 + 1077 WP_001076671.1 M42 family metallopeptidase -
HF084_RS11925 (2410801) 2410801..2411463 + 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
HF084_RS11930 (2411456) 2411456..2412232 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
HF084_RS11935 (2412628) 2412628..2413815 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T153742 WP_000074045.1 NZ_CP051191:2408856-2409122 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T153742 NZ_CP067067:181566-181853 [Raoultella sp. XY-1]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT153742 WP_000587619.1 NZ_CP051191:2408599-2408856 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT153742 NZ_CP067067:181327-181566 [Raoultella sp. XY-1]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References