Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1228437..1228851 | Replicon | chromosome |
| Accession | NZ_CP051191 | ||
| Organism | Staphylococcus aureus strain NGA102 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | HF084_RS06215 | Protein ID | WP_249739960.1 |
| Coordinates | 1228600..1228851 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | HF084_RS06210 | Protein ID | WP_168777632.1 |
| Coordinates | 1228437..1228610 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HF084_RS06165 (1224566) | 1224566..1225843 | - | 1278 | WP_216734469.1 | PBSX family phage terminase large subunit | - |
| HF084_RS06170 (1225830) | 1225830..1226270 | - | 441 | WP_001003271.1 | terminase small subunit | - |
| HF084_RS06175 (1226457) | 1226457..1226876 | - | 420 | WP_000058633.1 | transcriptional regulator | - |
| HF084_RS06180 (1226891) | 1226891..1227037 | - | 147 | WP_000989997.1 | hypothetical protein | - |
| HF084_RS06185 (1227038) | 1227038..1227211 | - | 174 | WP_070014293.1 | transcriptional activator RinB | - |
| HF084_RS06190 (1227208) | 1227208..1227414 | - | 207 | WP_054189015.1 | DUF1381 domain-containing protein | - |
| HF084_RS06195 (1227451) | 1227451..1227978 | - | 528 | WP_117216027.1 | dUTPase | - |
| HF084_RS06200 (1227993) | 1227993..1228154 | - | 162 | WP_168777631.1 | hypothetical protein | - |
| HF084_RS06205 (1228155) | 1228155..1228436 | - | 282 | WP_147701981.1 | hypothetical protein | - |
| HF084_RS06210 (1228437) | 1228437..1228610 | - | 174 | WP_168777632.1 | hypothetical protein | Antitoxin |
| HF084_RS06215 (1228600) | 1228600..1228851 | - | 252 | WP_249739960.1 | DUF1024 family protein | Toxin |
| HF084_RS06220 (1228844) | 1228844..1229152 | - | 309 | WP_249739961.1 | hypothetical protein | - |
| HF084_RS06225 (1229149) | 1229149..1229496 | - | 348 | WP_114621444.1 | YopX family protein | - |
| HF084_RS06230 (1229493) | 1229493..1229885 | - | 393 | WP_249739962.1 | hypothetical protein | - |
| HF084_RS06235 (1229900) | 1229900..1230142 | - | 243 | WP_000131370.1 | SAV1978 family virulence-associated passenger protein | - |
| HF084_RS06240 (1230146) | 1230146..1230514 | - | 369 | WP_000101275.1 | SA1788 family PVL leukocidin-associated protein | - |
| HF084_RS06245 (1230527) | 1230527..1230931 | - | 405 | Protein_1207 | RusA family crossover junction endodeoxyribonuclease | - |
| HF084_RS06250 (1230940) | 1230940..1231158 | - | 219 | WP_000338530.1 | hypothetical protein | - |
| HF084_RS06255 (1231165) | 1231165..1232049 | - | 885 | WP_031833239.1 | DnaD domain protein | - |
| HF084_RS06260 (1232079) | 1232079..1232549 | - | 471 | WP_249739963.1 | single-stranded DNA-binding protein | - |
| HF084_RS06265 (1232550) | 1232550..1233167 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1194789..1244186 | 49397 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9289.16 Da Isoelectric Point: 3.8810
>T153740 WP_249739960.1 NZ_CP051191:c1228851-1228600 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQG
NDY
MNNREQIEQSVISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQG
NDY
Download Length: 252 bp
>T153740 NZ_CP067066:4201411-4201629 [Raoultella sp. XY-1]
ATGTCTGGTGAACCATTAACCAAAACAGACTATTTGATGCGCTTACGTCGCTGTCAGACAATTGATACGCTGGAACGCGT
AATTGAAAAAAACAAATATGAACTTTCAGATAACGAACTGGCTGTATTTTACTCAGCGGCCGACCACCGTCTTGCTGAAT
TGACCATGAATAAGCTCTACGACAAAATCCCGACATCGGTGTGGAAGTTCATTCGCTAA
ATGTCTGGTGAACCATTAACCAAAACAGACTATTTGATGCGCTTACGTCGCTGTCAGACAATTGATACGCTGGAACGCGT
AATTGAAAAAAACAAATATGAACTTTCAGATAACGAACTGGCTGTATTTTACTCAGCGGCCGACCACCGTCTTGCTGAAT
TGACCATGAATAAGCTCTACGACAAAATCCCGACATCGGTGTGGAAGTTCATTCGCTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6482.32 Da Isoelectric Point: 4.2484
>AT153740 WP_168777632.1 NZ_CP051191:c1228610-1228437 [Staphylococcus aureus]
MTISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MTISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT153740 NZ_CP067066:4201010-4201384 [Raoultella sp. XY-1]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCGCAGCTTCGATTTCTTTGCGAAACCCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGTAACCACGGGTGGGTGAATGATCCAACGTCGGCTATCAATCTTCAACTTAATGAATTGATCGAAC
ACATAGCCACGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAACTGATCGCTCAGCTGGACGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGCATTAACACGGCCGATCTACAGAAATGGCGCAAATCGGGAAATCGGTT
ATTCCGATGTTTTGTCAACGCCAGTCGGGAAAATCCGGCAAGTCTTTCTTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATCGCGCAGCTTCGATTTCTTTGCGAAACCCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGTAACCACGGGTGGGTGAATGATCCAACGTCGGCTATCAATCTTCAACTTAATGAATTGATCGAAC
ACATAGCCACGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAACTGATCGCTCAGCTGGACGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGCATTAACACGGCCGATCTACAGAAATGGCGCAAATCGGGAAATCGGTT
ATTCCGATGTTTTGTCAACGCCAGTCGGGAAAATCCGGCAAGTCTTTCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|