Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 228534..229120 Replicon chromosome
Accession NZ_CP051190
Organism Xanthomonas sp. SS

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HEP74_RS01010 Protein ID WP_185814803.1
Coordinates 228534..228815 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HEP74_RS01015 Protein ID WP_185814804.1
Coordinates 228830..229120 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEP74_RS00995 224407..225102 - 696 WP_185816439.1 ribonuclease H-like domain-containing protein -
HEP74_RS01000 225519..225752 - 234 WP_185814801.1 hypothetical protein -
HEP74_RS01005 225865..228363 - 2499 WP_185814802.1 DEAD/DEAH box helicase -
HEP74_RS01010 228534..228815 + 282 WP_185814803.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEP74_RS01015 228830..229120 + 291 WP_185814804.1 HigA family addiction module antidote protein Antitoxin
HEP74_RS01020 229271..229933 + 663 WP_185814805.1 hemolysin III family protein -
HEP74_RS01025 230061..230513 + 453 WP_185814806.1 hypothetical protein -
HEP74_RS01030 230700..231119 - 420 WP_185814807.1 BA14K family protein -
HEP74_RS01035 231341..231634 - 294 WP_185814808.1 DUF2388 domain-containing protein -
HEP74_RS01040 231861..232052 - 192 WP_185814809.1 hypothetical protein -
HEP74_RS01045 232534..233445 - 912 WP_185814810.1 hypothetical protein -
HEP74_RS01050 233663..233890 - 228 WP_185816440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 225519..235219 9700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10714.29 Da        Isoelectric Point: 9.2716

>T153731 WP_185814803.1 NZ_CP051190:228534-228815 [Xanthomonas sp. SS]
VIRNFVDKEAEKIWQGTPSRRLPADIQAVARRKLRMLNSAATLDDLRVPPANLLEALKGNRKGQCSIRINDQWRVCFQWK
DGDALDVEIVDYH

Download         Length: 282 bp

>T153731 NZ_CP067060:c5350936-5350553 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10401.03 Da        Isoelectric Point: 10.5812

>AT153731 WP_185814804.1 NZ_CP051190:228830-229120 [Xanthomonas sp. SS]
MKTLPNIHPGEVLLEEFLTPLGISQNALARAAGVPPRRINEIVLGKRSVSADSAIRLAAALGTSERFWLGLQADYDLEQA
RRALGAQARKIERIAA

Download         Length: 291 bp

>AT153731 NZ_CP067060:c5351178-5350936 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References