Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 239538..240124 Replicon chromosome
Accession NZ_CP051189
Organism Xanthomonas sp. GW

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HEP73_RS01035 Protein ID WP_185821790.1
Coordinates 239538..239819 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HEP73_RS01040 Protein ID WP_179571181.1
Coordinates 239834..240124 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEP73_RS01025 235412..236107 - 696 WP_185823242.1 ribonuclease H-like domain-containing protein -
HEP73_RS01030 236869..239367 - 2499 WP_185821789.1 DEAD/DEAH box helicase -
HEP73_RS01035 239538..239819 + 282 WP_185821790.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HEP73_RS01040 239834..240124 + 291 WP_179571181.1 HigA family addiction module antidote protein Antitoxin
HEP73_RS01045 240273..240935 + 663 WP_185821791.1 hemolysin III family protein -
HEP73_RS01050 241063..241515 + 453 WP_185821792.1 hypothetical protein -
HEP73_RS01055 241702..242121 - 420 WP_185821793.1 BA14K family protein -
HEP73_RS01060 242342..242635 - 294 WP_185821794.1 DUF2388 domain-containing protein -
HEP73_RS01065 242818..243009 - 192 WP_185821795.1 hypothetical protein -
HEP73_RS01070 243189..243455 + 267 WP_185823243.1 nucleoside-diphosphate sugar epimerase -
HEP73_RS01075 243492..244403 - 912 WP_185821796.1 hypothetical protein -
HEP73_RS01080 244542..244769 - 228 WP_185823244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10757.32 Da        Isoelectric Point: 9.8979

>T153726 WP_185821790.1 NZ_CP051189:239538-239819 [Xanthomonas sp. GW]
VIRNFVDKEAEKIWQGTPSRRLPADIQAVARRKLRMLNSAATLDDLRVPPANRLEALKGNRKGQCSIRINDQWRVCFQWK
DGDALDVEIVDYH

Download         Length: 282 bp

>T153726 NZ_CP067060:2031953-2032055 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10413.08 Da        Isoelectric Point: 10.5812

>AT153726 WP_179571181.1 NZ_CP051189:239834-240124 [Xanthomonas sp. GW]
MKTLPNIHPGEVLLEEFLIPLGISQNALARAAGVPPRRINEIVLGKRSVSADSAIRLAAALGTSERFWLGLQADYDLEQA
RRALGAQARKIERIAA

Download         Length: 291 bp

>AT153726 NZ_CP067060:c2032062-2031917 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References