Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 198090..198931 Replicon plasmid pUW774mp
Accession NZ_CP051170
Organism Ralstonia solanacearum strain RUN2474

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag HF909_RS18810 Protein ID WP_193028733.1
Coordinates 198416..198931 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag HF909_RS18805 Protein ID WP_193028732.1
Coordinates 198090..198419 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF909_RS18775 193398..194258 + 861 WP_193037660.1 spermidine synthase -
HF909_RS18780 194413..194712 - 300 Protein_163 DUF1016 family protein -
HF909_RS18785 194791..195776 + 986 WP_193034960.1 IS630 family transposase -
HF909_RS18790 195801..196685 - 885 Protein_165 DUF1016 family protein -
HF909_RS18795 196744..196966 - 223 Protein_166 hypothetical protein -
HF909_RS18800 197174..197976 + 803 WP_193037662.1 IS5 family transposase -
HF909_RS18805 198090..198419 + 330 WP_193028732.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
HF909_RS18810 198416..198931 + 516 WP_193028733.1 type II toxin-antitoxin system YhaV family toxin Toxin
HF909_RS18815 199388..200284 + 897 WP_043899999.1 LysR family transcriptional regulator -
HF909_RS18820 200521..201399 + 879 WP_193037664.1 EamA family transporter -
HF909_RS18825 201935..203164 + 1230 WP_193037666.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - acrB / fliI / fliM / flgG / flgC / cyaB / motA / cheW / cheB / cheY / adeG 1..1942331 1942331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(16-152)

Antitoxin

PrlF antitoxin

(8-107)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19642.40 Da        Isoelectric Point: 9.6724

>T153707 WP_193028733.1 NZ_CP051170:198416-198931 [Ralstonia solanacearum]
MTAVQPVPLVIHGWTIFAHPLLLDQLDALTRQVEALREKDPSGYVKKNATKRLAAICKLAFDVIPQDPARPEYRQGHTLG
DENKHWFRAKFFQQYRLFFRFHAPSKMIVLAWINDADTKRAYESDDDAYRVFKRMLASGHPPNDWEPLLTEASRQSERLQ
STAGALGTGHR

Download         Length: 516 bp

>T153707 NZ_CP067045:c5294888-5294505 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12110.59 Da        Isoelectric Point: 4.4731

>AT153707 WP_193028732.1 NZ_CP051170:198090-198419 [Ralstonia solanacearum]
MPVTLEAESTLTDRYQTTVPETVRRALRLGKRDKIHYTIRQTGEVVLTRADDDEAADPVLGQFLRFLAQDIAAHPERLQG
LDTSLVQRIHTLVGGIEVDLDAALSADDE

Download         Length: 330 bp

>AT153707 NZ_CP067045:c5295130-5294888 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References