153688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2667815..2668229 Replicon chromosome
Accession NZ_CP051165
Organism Staphylococcus aureus strain NGA84b

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HF584_RS12935 Protein ID WP_147701982.1
Coordinates 2667815..2668066 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HF584_RS12940 Protein ID WP_168777632.1
Coordinates 2668056..2668229 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF584_RS12880 (2663183) 2663183..2663965 + 783 WP_053005614.1 AP2 domain-containing protein -
HF584_RS12885 (2663937) 2663937..2664740 + 804 WP_053005611.1 phage replisome organizer N-terminal domain-containing protein -
HF584_RS12890 (2664750) 2664750..2665529 + 780 WP_024928056.1 ATP-binding protein -
HF584_RS12895 (2665523) 2665523..2665681 + 159 WP_000256594.1 hypothetical protein -
HF584_RS12900 (2665694) 2665694..2665915 + 222 WP_249740035.1 DUF3269 family protein -
HF584_RS12905 (2665926) 2665926..2666330 + 405 WP_000049801.1 DUF1064 domain-containing protein -
HF584_RS12910 (2666335) 2666335..2666520 + 186 WP_001187233.1 DUF3113 family protein -
HF584_RS12915 (2666521) 2666521..2666880 + 360 WP_000029389.1 SA1788 family PVL leukocidin-associated protein -
HF584_RS12920 (2666881) 2666881..2667129 + 249 WP_001126840.1 phi PVL orf 51-like protein -
HF584_RS12925 (2667143) 2667143..2667547 + 405 WP_249740036.1 hypothetical protein -
HF584_RS12930 (2667547) 2667547..2667822 + 276 Protein_2540 hypothetical protein -
HF584_RS12935 (2667815) 2667815..2668066 + 252 WP_147701982.1 DUF1024 family protein Toxin
HF584_RS12940 (2668056) 2668056..2668229 + 174 WP_168777632.1 hypothetical protein Antitoxin
HF584_RS12945 (2668230) 2668230..2668511 + 282 WP_147701981.1 hypothetical protein -
HF584_RS12950 (2668512) 2668512..2668673 + 162 WP_168777631.1 hypothetical protein -
HF584_RS12955 (2668688) 2668688..2669215 + 528 WP_221921001.1 dUTPase -
HF584_RS12960 (2669252) 2669252..2669458 + 207 WP_249740037.1 DUF1381 domain-containing protein -
HF584_RS12965 (2669455) 2669455..2669658 + 204 WP_001072794.1 hypothetical protein -
HF584_RS12970 (2669651) 2669651..2669887 + 237 WP_000608278.1 hypothetical protein -
HF584_RS12975 (2669877) 2669877..2670266 + 390 WP_001662395.1 hypothetical protein -
HF584_RS12980 (2670263) 2670263..2670436 + 174 WP_000595256.1 transcriptional activator RinB -
HF584_RS12985 (2670437) 2670437..2670583 + 147 WP_000990006.1 hypothetical protein -
HF584_RS12990 (2670598) 2670598..2671017 + 420 WP_000058632.1 transcriptional regulator -
HF584_RS12995 (2671204) 2671204..2671644 + 441 WP_001003271.1 terminase small subunit -
HF584_RS13000 (2671631) 2671631..2672908 + 1278 WP_111174542.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2654465..2698363 43898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9304.17 Da        Isoelectric Point: 3.8362

>T153688 WP_147701982.1 NZ_CP051165:2667815-2668066 [Staphylococcus aureus]
MDNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQG
NDY

Download         Length: 252 bp

>T153688 NZ_CP067032:c1664193-1663924 [Agrobacterium fabrum]
ATGAAGCTCGTCTGGACGCTGAGTTCATGGGACGACTATGAGTTCTGGCAAAGAACCGATGCTCGCATGGTCGAGAAAAT
AAACGATCTTATCCGAAATGCCAAACGCACGCCCTTTGCAGGGCTTGGGAAACCGGAGCCTCTGAAGGGCGATATGGCAG
GATATTGGTCTCGGCGGATTACCGCCGAGCATCGGTTTGTCTACCGTGTATCCGGGTCCGGAAGCGAGCAACGGCTGGAA
GTCATTCAGTGCCGCTTCCATTACCAATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6482.32 Da        Isoelectric Point: 4.2484

>AT153688 WP_168777632.1 NZ_CP051165:2668056-2668229 [Staphylococcus aureus]
MTISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT153688 NZ_CP067032:c1664444-1664190 [Agrobacterium fabrum]
ATGGCGAATGTGCGATTTACCGAGTTCAGGCAGAACTTCGCGACCCATTTCGACCGGGTTCTGGAAACCCGCGCGCCATT
GCTCGTCACGCGGCAAGGCAAAGAGGCGGTCGTGGTGCTTGCCGAAGGAGAATATGAGAGCATGCAGGAAACGCTGCATC
TCCTGTCCAACCCGGCAAATGCCTCAAGGCTTCGCGCGTCCATGGGCGAACTTGAGCGCGGTGACACCATCGAGCGGGAT
CCGACCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References