Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2185851..2186368 Replicon chromosome
Accession NZ_CP051165
Organism Staphylococcus aureus strain NGA84b

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HF584_RS10425 Protein ID WP_054189942.1
Coordinates 2186102..2186368 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HF584_RS10420 Protein ID WP_054189941.1
Coordinates 2185851..2186102 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF584_RS10390 (2181550) 2181550..2182269 + 720 WP_054189936.1 amino acid ABC transporter permease -
HF584_RS10395 (2182266) 2182266..2182997 + 732 WP_054189937.1 amino acid ABC transporter ATP-binding protein -
HF584_RS10400 (2183092) 2183092..2184342 - 1251 WP_054189938.1 FemA/FemB family glycyltransferase FmhA -
HF584_RS10405 (2184598) 2184598..2184960 + 363 WP_054189939.1 DUF4467 domain-containing protein -
HF584_RS10410 (2184979) 2184979..2185578 + 600 WP_054189940.1 DsbA family protein -
HF584_RS10415 (2185585) 2185585..2185686 + 102 Protein_2051 hypothetical protein -
HF584_RS10420 (2185851) 2185851..2186102 + 252 WP_054189941.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HF584_RS10425 (2186102) 2186102..2186368 + 267 WP_054189942.1 Txe/YoeB family addiction module toxin Toxin
HF584_RS10430 (2186403) 2186403..2186474 + 72 WP_223200558.1 hypothetical protein -
HF584_RS10435 (2186662) 2186662..2188209 + 1548 WP_054189943.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HF584_RS10440 (2188395) 2188395..2188862 + 468 WP_054189944.1 SRPBCC domain-containing protein -
HF584_RS10445 (2188949) 2188949..2189131 + 183 WP_054189945.1 hypothetical protein -
HF584_RS10450 (2189334) 2189334..2190158 + 825 WP_000594640.1 formate/nitrite transporter family protein -
HF584_RS10455 (2190627) 2190627..2191163 + 537 WP_249740026.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10393.94 Da        Isoelectric Point: 10.0573

>T153685 WP_054189942.1 NZ_CP051165:2186102-2186368 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMALKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T153685 NZ_CP067032:c355118-354849 [Agrobacterium fabrum]
GTGATCTGGACAATTGAATATCACACGCTTGTGCAGAAAGAGATGCGCAAAATAAATCCGGAAGTGCGCCGGCGCATCCG
CAGTTTTCTCCATGAAAGGCTGGCCGCACTGGACGACCCGCGCCAGATCGGCGCTACACTGCAAGGTTCCGAACTCGGAA
ATTTCTGGCGTTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGACCAAAAGCTGGTCGTTCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATTTACCGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.69 Da        Isoelectric Point: 4.3407

>AT153685 WP_054189941.1 NZ_CP051165:2185851-2186102 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTIMKD
IDV

Download         Length: 252 bp

>AT153685 NZ_CP067032:c355329-355102 [Agrobacterium fabrum]
ATGAGCAAACAGACGGCCATTCGCCTGCCGGACGAGACCTATGAGCGGCTGAAGGCGCTGTCTGAGCGGACCGGCCGCAC
ATCCGCCTATTATATCCGCGAGGCGATCGAGAAGCATATCGAGGATATGGAAGACCTCTATCTTGCCGAAGAGGCGACGC
GGCGCATTCAGCGCGGAGAATCGAAGATTATAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References