Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2133614..2134137 Replicon chromosome
Accession NZ_CP051165
Organism Staphylococcus aureus strain NGA84b

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HF584_RS10160 Protein ID WP_054189905.1
Coordinates 2133871..2134137 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HF584_RS10155 Protein ID WP_020977565.1
Coordinates 2133614..2133871 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF584_RS10135 (2128693) 2128693..2129886 + 1194 WP_006191034.1 MFS transporter -
HF584_RS10140 (2130110) 2130110..2130859 - 750 WP_054189903.1 CPBP family lipoprotein N-acylation protein LnsB -
HF584_RS10145 (2131054) 2131054..2132631 + 1578 WP_054189904.1 FMN-binding glutamate synthase family protein -
HF584_RS10150 (2132799) 2132799..2133254 - 456 WP_000732082.1 DUF1307 domain-containing protein -
HF584_RS10155 (2133614) 2133614..2133871 + 258 WP_020977565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HF584_RS10160 (2133871) 2133871..2134137 + 267 WP_054189905.1 Txe/YoeB family addiction module toxin Toxin
HF584_RS10165 (2134491) 2134491..2135567 + 1077 WP_054189906.1 M42 family metallopeptidase -
HF584_RS10170 (2135917) 2135917..2136579 + 663 WP_025786559.1 ATP-binding cassette domain-containing protein -
HF584_RS10175 (2136572) 2136572..2137348 + 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
HF584_RS10180 (2137742) 2137742..2138929 + 1188 WP_054189907.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10587.19 Da        Isoelectric Point: 10.1603

>T153684 WP_054189905.1 NZ_CP051165:2133871-2134137 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKITHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRGVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T153684 NZ_CP067027:c1662055-1661786 [Agrobacterium fabrum]
ATGAAGCTCGTCTGGACGCTGAGTTCATGGGACGACTATGAGTTCTGGCAAAGAACCGATGCTCGCATGGTCGAGAAAAT
AAACGATCTTATCCGAAATGCCAAACGCACGCCCTTTGCAGGGCTTGGGAAACCGGAGCCTCTGAAGGGCGATATGGCAG
GATATTGGTCTCGGCGGATTACCGCCGAGCATCGGTTTGTCTACCGTGTATCCGGGTCCGGAAGCGAGCAACGGCTGGAA
GTCATTCAGTGCCGCTTCCATTACCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9796.79 Da        Isoelectric Point: 4.3304

>AT153684 WP_020977565.1 NZ_CP051165:2133614-2133871 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT153684 NZ_CP067027:c1662306-1662052 [Agrobacterium fabrum]
ATGGCGAATGTGCGATTTACCGAGTTCAGGCAGAACTTCGCGACCCATTTCGACCGGGTTCTGGAAACCCGCGCGCCATT
GCTCGTCACGCGGCAAGGCAAAGAGGCGGTCGTGGTGCTTGCCGAAGGAGAATATGAGAGCATGCAGGAAACGCTGCATC
TCCTGTCCAACCCGGCAAATGCCTCAAGGCTTCGCGCGTCCATGGGCGAACTTGAGCGCGGTGACACCATCGAGCGGGAT
CCGACCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References