Detailed information of TA system TA153680

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 364412..364991
• Replicon: chromosome
• Accession: NZ_CP051165
• Organism: Staphylococcus aureus strain NGA84b

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HF584_RS01835
• Protein ID: WP_001025401.1
• Coordinates: 364412..364657 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	364626..364991 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF584_RS01785 (360296)	360296..360910	+	615	WP_000191466.1	hypothetical protein	-
HF584_RS01790 (360907)	360907..361053	-	147	WP_001795334.1	hypothetical protein	-
HF584_RS01795 (361143)	361143..361538	-	396	WP_000449655.1	hypothetical protein	-
HF584_RS01800 (361567)	361567..362001	-	435	WP_000755718.1	hypothetical protein	-
HF584_RS01805 (362019)	362019..362480	-	462	WP_000525004.1	hypothetical protein	-
HF584_RS01810 (362493)	362493..362807	-	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
HF584_RS01815 (362959)	362959..363195	+	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
HF584_RS01820 (363209)	363209..363985	+	777	WP_001148544.1	Rha family transcriptional regulator	-
HF584_RS01825 (364014)	364014..364157	+	144	WP_000939498.1	hypothetical protein	-
HF584_RS01830 (364147)	364147..364356	-	210	WP_000642492.1	hypothetical protein	-
HF584_RS01835 (364412)	364412..364657	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HF584_RS01840 (364626)	364626..364991	-	366	WP_001128433.1	hypothetical protein	Antitoxin
HF584_RS01845 (365046)	365046..365261	+	216	WP_001097552.1	hypothetical protein	-
HF584_RS01850 (365286)	365286..365549	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
HF584_RS01855 (365562)	365562..365723	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
HF584_RS01860 (365802)	365802..366125	+	324	WP_000175001.1	hypothetical protein	-
HF584_RS01865 (366140)	366140..366502	+	363	WP_000985984.1	hypothetical protein	-
HF584_RS01870 (366499)	366499..367665	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
HF584_RS01875 (367691)	367691..368248	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	dfrG	lukS-PV / lukF-PV	354338..408893	54555

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T153680 WP_001025401.1 NZ_CP051165:364412-364657 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T153680 NZ_CP051165:364412-364657 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT153680 NZ_CP051165:c364991-364626 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin