Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3848784..3849381 Replicon chromosome
Accession NZ_CP051161
Organism Klebsiella pneumoniae strain 16BU137

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag HF572_RS18960 Protein ID WP_004893639.1
Coordinates 3849064..3849381 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag HF572_RS18955 Protein ID WP_004142561.1
Coordinates 3848784..3849071 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF572_RS18925 3844991..3845239 + 249 WP_002893037.1 DUF1158 domain-containing protein -
HF572_RS18930 3845257..3845598 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
HF572_RS18935 3845629..3846744 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
HF572_RS18940 3846924..3847505 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
HF572_RS18945 3847505..3847873 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
HF572_RS18950 3847993..3848646 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
HF572_RS18955 3848784..3849071 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
HF572_RS18960 3849064..3849381 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF572_RS18965 3849566..3850609 - 1044 WP_023279204.1 DUF2157 domain-containing protein -
HF572_RS18970 3851279..3852145 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
HF572_RS18975 3852254..3853681 + 1428 WP_105910454.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T153665 WP_004893639.1 NZ_CP051161:c3849381-3849064 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T153665 NZ_CP067019:2410839-2411771 [Acinetobacter sp. CS-2]
TTGCCAGCTAAAAGAATTGAACATGCTTTAAAATATTTACGTACGGAAAATCCATCCCCTGTCTCTAGCTCTACAGGTAA
ATCCTGGTCTAGAAATCCTGTTCATTATAAATTAAATACAGATCATATTAGTAAGATAACTGCTATTAGAGAACAAGAAT
GGCAACAAATGCTTCAATTTATCAATACTGATAAATGCTATATGCATTTAGTCAGAGAATATCTGGATGACAAAAATACT
GATAAATGTGGAATTTGTTCTAATTGTATATCCGAGCCTCTTATAGATATCAAGATTAATTCAAATCTCGCAAATAAAGC
TGCGAGTTTTATTAAACATACCGAACAACCTATAGAACCACGTAAGCAAATTGCTACTTCAAATGAAGAACATATAAATA
CTTTTAAAATATATACACTCCCTAGACAGTTAGGTTCTTTAAGTGCTCAAGAAGGAAGAGTTTTATCTCGCTGGGGTGAT
GCGGGCTGGGGACATCTCGTTAAAGAAGGTAAAGAAAAAAATTACTTTAGTGATGAATTAGTAAATGCTGTTGCTGATAT
GATAACTCAACGATGGAAACCTAGTCCTACTCCTCAATGGATATGTTGTGTACCTTCGTTAAATCATAAAACTCTTGTAC
CTGATTTTGCAGCAAAATTAGCCAATAAGCTAGGTATTCCGTTTATTGATGTTATTTCTAAAATTAAAGAGAATGAACCT
CAGAAGTTCCAAAACAATAGATTCCACCAATGTAAAAATTTAGATGGTGTATTCGAAATTTCGAGTAAAATTCCTAATAG
CCCTGTTCTTCTTATAGATGACATGGTCGATTCCCGATGGACCTTCACCGTTATTGCTGCTCTACTTAGGCAGCATGGAA
GTGGTGAAGTATTTCCTGTCGCTCTAGCATCCACTTCGGTAAACGAATCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT153665 WP_004142561.1 NZ_CP051161:c3849071-3848784 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT153665 NZ_CP067019:2411768-2413051 [Acinetobacter sp. CS-2]
ATGAATTTAAGCAAAAGCTCTCAAGCGATTATTCTATTAACTAGTTATTTTACCAAAGCTAATGACTCTGAGCATAAACC
GCTGACACCTACTGAATGGGGAAGATTCGCAAAGTGGCTTCATGAGAATCAGCATACTCCTGAAGATTTACTTACTCGTG
AAGTAAAAGATATTTTAATAGAATGGCAAGATCCAAAAATTTCTAGTACTCGCCTATTATATCTACTAGGCCGTGGTCAT
AGTATGGCATTAAACTTGGAAAAATGGTCAAGGTCTGGACTCTGGGTAATCACTAGAGCTGATAGTGAATATCCTTGGCG
CTTAAAACAGAGACTCAAGCAGGATGCACCACCTGTATTATTTGGGTGTGGTTCAAAAGAATTATTAAATTATCCTGGAC
TCGCTGTTGTTGGCTCAAGAAGTGCCAATGTATCTGATTTGAAATATGCTGAAACTATTGGAGCGAAAGCATCTTTCGAA
AGTGTCTCCATTATTTCTGGTGGAGCTAAAGGTATTGATGAAAGTGCTATGCTTGGTGCTGTAAATAATCACGGTATGAC
CGTCGGTGTAATGGCTGACAGTTTACTTAAGCATATTACAAGCAAAAAATGGCGCTCTGCACTGATGAATGAACAAGCTG
TTCTCATCTCTCCGTTTTATCCTGAAGCAGGATTCTCGACTGGAAATGCAATGGCAAGAAATAAGTATATTTATTGTTTA
GCAGATTCAAGTTTAGTAGTGCACTCGGGGCTTAAAGGAGGAACCATTGCTGGTGCTCAAGAAAACCTGAGAAAAGGTTG
GGTTCCTATATATATAAAACCTAATGATGATCAAAACTCAGCTAATACTTTCTTGATCAATCAAGGTGGTAGACCTATAA
ATACTACTCTCGATAATTTATCAATTATAGAACATCTATTCAAACTTGATCTACCTATAGAATCCCACCCTCCTGTTGAT
GTGATTAATCACCAGATTGATATGTTCAACCCAAACCCAAACCCAAACCCAAACCCAAACCCAAACCCAAACCCAAACCC
AAACCCAAACCCAAACCCAAACCCAAACCCAAACCCAAACCCAAAAGATTTTGTGAAAAATTTTGATTTTTACAATTATT
TCTTGGATTTTTTACGAGAAGCAAATTTAGATGAAAGCACTGTCGACGAAATCATTCAACATTCTAAATTACATAAATCA
CAAGTAAATGAATGGTTAAAAATAGCCATTAGTGAAAGAAAAATTCAAAAAATGAACAAACCCGTAAGATATAAACTTTT
ATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References