Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 734972..735747 | Replicon | chromosome |
Accession | NZ_CP051161 | ||
Organism | Klebsiella pneumoniae strain 16BU137 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | A0A1Q4Q548 |
Locus tag | HF572_RS03645 | Protein ID | WP_004150910.1 |
Coordinates | 735262..735747 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | W8UEW1 |
Locus tag | HF572_RS03640 | Protein ID | WP_004150912.1 |
Coordinates | 734972..735265 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HF572_RS03620 | 730180..730782 | - | 603 | WP_002916735.1 | short chain dehydrogenase | - |
HF572_RS03625 | 730880..731791 | + | 912 | WP_105910473.1 | LysR family transcriptional regulator | - |
HF572_RS03630 | 731792..732940 | - | 1149 | WP_004150915.1 | PLP-dependent aspartate aminotransferase family protein | - |
HF572_RS03635 | 732951..734327 | - | 1377 | WP_004217775.1 | cystathionine beta-synthase | - |
HF572_RS03640 | 734972..735265 | + | 294 | WP_004150912.1 | DUF1778 domain-containing protein | Antitoxin |
HF572_RS03645 | 735262..735747 | + | 486 | WP_004150910.1 | GNAT family N-acetyltransferase | Toxin |
HF572_RS03650 | 736451..737044 | + | 594 | WP_105434476.1 | hypothetical protein | - |
HF572_RS03655 | 737141..737357 | + | 217 | Protein_718 | transposase | - |
HF572_RS03660 | 737982..739052 | - | 1071 | WP_105910474.1 | ParA family protein | - |
HF572_RS03665 | 739195..739533 | - | 339 | WP_045337778.1 | hypothetical protein | - |
HF572_RS03670 | 739558..740109 | - | 552 | WP_045337779.1 | recombinase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 737141..737293 | 152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17551.59 Da Isoelectric Point: 8.8818
>T153654 WP_004150910.1 NZ_CP051161:735262-735747 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
Download Length: 486 bp
>T153654 NZ_CP067005:c4708840-4708688 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTAACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTAACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10901.46 Da Isoelectric Point: 6.3783
>AT153654 WP_004150912.1 NZ_CP051161:734972-735265 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
Download Length: 294 bp
>AT153654 NZ_CP067005:c4708608-4708474 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q4Q548 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GVL4 |