Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2694438..2694948 Replicon chromosome
Accession NZ_CP051153
Organism Treponema vincentii strain OMZ 862

Toxin (Protein)


Gene name yoeB Uniprot ID S3LB99
Locus tag E4N73_RS12405 Protein ID WP_016518798.1
Coordinates 2694688..2694948 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S3LAR5
Locus tag E4N73_RS12400 Protein ID WP_016518797.1
Coordinates 2694438..2694695 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N73_RS12375 (E4N73_12440) 2690227..2690712 - 486 WP_006187617.1 pantetheine-phosphate adenylyltransferase -
E4N73_RS12380 (E4N73_12445) 2691328..2691906 - 579 WP_253807450.1 hypothetical protein -
E4N73_RS12385 (E4N73_12450) 2691875..2692345 - 471 WP_253728075.1 hypothetical protein -
E4N73_RS12390 (E4N73_12455) 2692451..2693188 - 738 WP_253807451.1 hypothetical protein -
E4N73_RS12395 (E4N73_12460) 2693694..2694245 - 552 WP_253807452.1 hypothetical protein -
E4N73_RS12400 (E4N73_12465) 2694438..2694695 + 258 WP_016518797.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E4N73_RS12405 (E4N73_12470) 2694688..2694948 + 261 WP_016518798.1 Txe/YoeB family addiction module toxin Toxin
E4N73_RS12410 (E4N73_12475) 2695079..2698582 - 3504 WP_253807453.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10606.11 Da        Isoelectric Point: 9.7986

>T153587 WP_016518798.1 NZ_CP051153:2694688-2694948 [Treponema vincentii]
MNKLFTDEAWDDYTFWFNTDKKILKKINDLIKEIERTPFTGKGKPEPLKYSLSGYWSRRINHEHRIVYQVDNDQLVFISF
RYHYKK

Download         Length: 261 bp

>T153587 NZ_CP066980:c4716428-4716276 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTAACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10191.52 Da        Isoelectric Point: 6.3284

>AT153587 WP_016518797.1 NZ_CP051153:2694438-2694695 [Treponema vincentii]
MDVITYSDLRRNLKTYMDKVYYDYEPLLIARKNSENLVLLSVHEYNSLIETDYLLRDEANAKHLKKSVEQHKNGHLQKHE
LLENE

Download         Length: 258 bp

>AT153587 NZ_CP066980:c4716196-4716062 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3LB99

Antitoxin

Source ID Structure
AlphaFold DB S3LAR5

References