Detailed information of TA system TA153585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-Phd
• Location: 471257..471759
• Replicon: chromosome
• Accession: NZ_CP051153
• Organism: Treponema vincentii strain OMZ 862

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: E4N73_RS02470
• Protein ID: WP_253807812.1
• Coordinates: 471257..471517 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: S3LA43
• Locus tag: E4N73_RS02475
• Protein ID: WP_016519149.1
• Coordinates: 471517..471759 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N73_RS02460 (E4N73_02455)	467408..469543	+	2136	WP_253807810.1	single-stranded-DNA-specific exonuclease RecJ	-
E4N73_RS02465 (E4N73_02460)	469772..470995	-	1224	WP_253807811.1	M20 family metallopeptidase	-
E4N73_RS02470 (E4N73_02465)	471257..471517	-	261	WP_253807812.1	Txe/YoeB family addiction module toxin	Toxin
E4N73_RS02475 (E4N73_02470)	471517..471759	-	243	WP_016519149.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E4N73_RS02480 (E4N73_02475)	471911..473416	+	1506	WP_253807813.1	hemolysin family protein	-
E4N73_RS02485 (E4N73_02480)	473413..474675	+	1263	WP_253807815.1	hemolysin family protein	-
E4N73_RS02490 (E4N73_02485)	474830..476044	+	1215	WP_253807816.1	galactokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10377.10 Da
• Isoelectric Point: 9.9941

>T153585 WP_253807812.1 NZ_CP051153:c471517-471257 [Treponema vincentii]
MWTVVYSKQAAKDSKKIELSNLKQTVKYLIEVIKNNPFENPPPYEKLVGDLAGKYSRRINIQHRLIYEVFEKEHIVRILR
MWTHYE

Nucleotide

• Length: 261 bp

>T153585 NZ_CP066980:c1430518-1430027 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCTA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9149.41 Da
• Isoelectric Point: 4.1191

>AT153585 WP_016519149.1 NZ_CP051153:c471759-471517 [Treponema vincentii]
MTILTATAARINLYNLIDQTKEFHEPIIISGKRNNAVLISEDDWDAIQETLYLCSIPGMRESIIEASKEPLEESIKELDW

Nucleotide

• Length: 243 bp

>AT153585 NZ_CP066980:c1430805-1430515 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Structures

Antitoxin

• AlphaFold DB: S3LA43