Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2618193..2618703 Replicon chromosome
Accession NZ_CP051148
Organism Treponema vincentii strain OMZ 861

Toxin (Protein)


Gene name yoeB Uniprot ID S3LB99
Locus tag E4N72_RS11875 Protein ID WP_016518798.1
Coordinates 2618443..2618703 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S3LAR5
Locus tag E4N72_RS11870 Protein ID WP_016518797.1
Coordinates 2618193..2618450 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N72_RS11835 (E4N72_11925) 2613478..2613963 - 486 WP_006187617.1 pantetheine-phosphate adenylyltransferase -
E4N72_RS11840 (E4N72_11930) 2613985..2614365 - 381 WP_253812676.1 hypothetical protein -
E4N72_RS11845 (E4N72_11935) 2614589..2615167 - 579 WP_253812678.1 hypothetical protein -
E4N72_RS11850 (E4N72_11940) 2615136..2615606 - 471 WP_253812680.1 hypothetical protein -
E4N72_RS11855 (E4N72_11945) 2615700..2616437 - 738 WP_253812682.1 hypothetical protein -
E4N72_RS11860 (E4N72_11950) 2616948..2617328 - 381 WP_253812683.1 hypothetical protein -
E4N72_RS11865 (E4N72_11955) 2617519..2617920 - 402 WP_016518796.1 hypothetical protein -
E4N72_RS11870 (E4N72_11960) 2618193..2618450 + 258 WP_016518797.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
E4N72_RS11875 (E4N72_11965) 2618443..2618703 + 261 WP_016518798.1 Txe/YoeB family addiction module toxin Toxin
E4N72_RS11880 (E4N72_11970) 2618834..2622316 - 3483 WP_253812684.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10606.11 Da        Isoelectric Point: 9.7986

>T153579 WP_016518798.1 NZ_CP051148:2618443-2618703 [Treponema vincentii]
MNKLFTDEAWDDYTFWFNTDKKILKKINDLIKEIERTPFTGKGKPEPLKYSLSGYWSRRINHEHRIVYQVDNDQLVFISF
RYHYKK

Download         Length: 261 bp

>T153579 NZ_CP066978:426266-426418 [Xanthomonas campestris pv. incanae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10191.52 Da        Isoelectric Point: 6.3284

>AT153579 WP_016518797.1 NZ_CP051148:2618193-2618450 [Treponema vincentii]
MDVITYSDLRRNLKTYMDKVYYDYEPLLIARKNSENLVLLSVHEYNSLIETDYLLRDEANAKHLKKSVEQHKNGHLQKHE
LLENE

Download         Length: 258 bp

>AT153579 NZ_CP066978:426495-426629 [Xanthomonas campestris pv. incanae]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3LB99

Antitoxin

Source ID Structure
AlphaFold DB S3LAR5

References