Detailed information of TA system TA153543

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2893138..2893474
• Replicon: chromosome
• Accession: NZ_CP051005
• Organism: Enterococcus faecalis strain TH4125

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: GRB94_RS14250
• Protein ID: WP_002396786.1
• Coordinates: 2893138..2893281 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2893425..2893474 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GRB94_RS14230	2888354..2888569	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
GRB94_RS14235	2888708..2889700	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
GRB94_RS14240	2889867..2890505	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
GRB94_RS14245	2891190..2892806	+	1617	WP_128701330.1	phosphatase PAP2/LCP family protein	-
GRB94_RS14250	2893138..2893281	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2893425..2893474	+	50	-	-	Antitoxin
GRB94_RS14255	2893476..2898167	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T153543 WP_002396786.1 NZ_CP051005:2893138-2893281 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T153543 NZ_CP066956:3793760-3794251 [Xanthomonas campestris pv. incanae]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGGTGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGCCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Nucleotide

• Length: 50 bp

>AT153543 NZ_CP051005:2893425-2893474 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin