Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1851432..1851945 Replicon chromosome
Accession NZ_CP051004
Organism Streptococcus agalactiae 515

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag GRB95_RS09455 Protein ID WP_000481712.1
Coordinates 1851432..1851686 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag GRB95_RS09460 Protein ID WP_000387490.1
Coordinates 1851679..1851945 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GRB95_RS09435 1847203..1849704 - 2502 WP_000239406.1 ATP-binding protein -
GRB95_RS09440 1849725..1850135 - 411 WP_000390749.1 conjugal transfer protein -
GRB95_RS09445 1850139..1850405 - 267 WP_001055037.1 hypothetical protein -
GRB95_RS09450 1850426..1851379 - 954 WP_000565541.1 conjugal transfer protein -
GRB95_RS09455 1851432..1851686 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
GRB95_RS09460 1851679..1851945 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GRB95_RS09465 1852090..1852563 - 474 WP_000560386.1 hypothetical protein -
GRB95_RS09470 1852571..1853053 - 483 WP_000383283.1 antirestriction protein ArdA -
GRB95_RS09475 1853106..1853378 - 273 WP_000072643.1 hypothetical protein -
GRB95_RS09480 1853510..1853863 - 354 WP_000571928.1 helix-turn-helix domain-containing protein -
GRB95_RS09485 1853856..1854086 - 231 WP_001866982.1 helix-turn-helix domain-containing protein -
GRB95_RS09490 1854073..1854450 - 378 WP_000287185.1 hypothetical protein -
GRB95_RS09495 1854466..1855698 - 1233 WP_000338839.1 replication initiation factor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb 1836265..1875862 39597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T153528 WP_000481712.1 NZ_CP051004:c1851686-1851432 [Streptococcus agalactiae 515]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T153528 NZ_CP066947:c4708927-4708793 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT153528 WP_000387490.1 NZ_CP051004:c1851945-1851679 [Streptococcus agalactiae 515]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT153528 NZ_CP066947:c4709156-4709004 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References